Chronic one-kidney hypertension in rabbits. I. Treatment with kidney extracts.

Circulation Research
L T SKEGGSK E LENTZ

Abstract

An investigation into the mechanism that sustains the blood pressure in chronic one-kidney hypertension in rabbits was made using passive and active immunization with hog kidney extracts containing renin and with angiotensin antagonists. Seven hypertensive rabbits were passively immunized for extended periods with antiserum prepared in other rabbits. Antirenin levels were in the range of 1-3 units/ml. Control experiments demonstrated that antirenin concentrations of 1.0 unit/ml or more eliminated more than 99% of the pressor response to renin. There was no lowering of blood pressure that could be attributed to the antibodies. No decrease in blood pressure was observed in 13 experiments in 7 rabbits given the angiotensin II antagonist 1-Sar-8-Ile-angiotensin II; infusion rates of 0.09-87 mug/min kg-1 were used for periods of a few hours up to 3 days. A reduction in blood pressure occurred in 16 of 19 rabbits immunized directly with extracts containing renin with specific activities of 9.6-757 GU/mg. Plasma antirenin titers correlated poorly with reductions in blood pressure. The blood pressure of 22 rabbits given equal amounts of protein without renin was unaffected. It is concluded that the elevation of blood pressure in rabbit...Continue Reading

References

Feb 3, 1975·Biochemical and Biophysical Research Communications·K Murakami, T Inagami
Nov 1, 1975·Circulation Research·J C RomeroC G Strong
Aug 1, 1969·The Journal of Clinical Investigation·A R ChristliebR B Hickler
Mar 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·I Eide, H Aars
Aug 1, 1972·Journal of Medicinal Chemistry·M C KhoslaF M Bumpus
Jan 1, 1973·Circulation Research·J Di SalvoT W Sanders
Nov 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J A JohnsonR H Freeman
Sep 18, 1973·Biochemical and Biophysical Research Communications·K MurakamiS Cohen
Jun 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·S L EngelB Rubin
Oct 1, 1973·The American Journal of Physiology·J C RomeroR J Warzynski
Aug 1, 1971·Journal of Applied Physiology·B Brooks, E E Muirhead
Feb 1, 1953·Archives of Biochemistry and Biophysics·E HAASH GOLDBLATT
Feb 1, 1954·Archives of Biochemistry and Biophysics·E HAASH GOLDBLATT
Apr 1, 1954·The American Journal of Physiology·H LAMFROMH GOLDBLATT
Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·S H KREMEN, G E WAKERLIN
Dec 1, 1959·The American Journal of Physiology·E HAAS, H GOLDBLATT
Mar 1, 1964·The Journal of Experimental Medicine·S D DEODHARH GOLDBLATT
May 21, 1934·The Journal of Physiology·R T Grant, P Rothschild

❮ Previous
Next ❯

Citations

Mar 19, 2014·International Heart Journal·Hironori NakagamiRyuichi Morishita
Jan 1, 2014·Vaccines·Hironori NakagamiRyuichi Morishita
May 12, 2010·Expert Opinion on Biological Therapy·Thong Huy DoSorot Phisitkul
Feb 13, 2015·Expert Opinion on Biological Therapy·Hironori Nakagami, Ryuichi Morishita
May 31, 1976·The American Journal of Medicine·L T SkeggsM Levine
Mar 1, 1989·American Heart Journal·J B MichelJ Ménard
May 1, 1977·Circulation Research·J O Davis
Sep 1, 1976·Circulation Research·L T SkeggsK E Lentz
Apr 1, 1979·Kidney International·E Haber
Oct 1, 1979·La Ricerca in Clinica E in Laboratorio·E Haber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the Society for Experimental Biology and Medicine
S H KREMEN, G E WAKERLIN
Biochimica Et Biophysica Acta
H J Lee, I B Wilson
Clinical and Experimental Hypertension. Part A, Theory and Practice
J M WoodK G Hofbauer
© 2022 Meta ULC. All rights reserved