Chronic opiate exposure in the male rat adversely affects fertility

Pharmacology, Biochemistry, and Behavior
Theodore J CiceroM S Schlegel

Abstract

We examined whether morphine administration to adult male rats adversely affected pregnancy outcome after mating with drug-naive females and at what point in the complex series of steps leading to viable offspring it exerted its actions. The results indicate that chronic paternal morphine exposure markedly influenced fertility measures in a number of important ways. There was a pronounced increase in pseudopregnancies in females mated with males treated chronically with morphine (40%) when compared to controls (<6%), indicating that vaginal penetration occurred, but successful impregnation failed; only 33% of matings between drug-naive females and morphine-treated males resulted in pregnancies, as compared to 74.5% in controls. In addition, there were fewer implantation sites in gravid females mated with morphine-treated males than in controls. Taken together, these observations suggest that morphine-exposed male rats were apparently able to copulate, but there was a failure in successful impregnation of the females. These findings suggest a primary defect in either the quality of male sexual behavior or a complete failure of the fertilization or conception processes in females mated with morphine-exposed males. This potentiall...Continue Reading

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Nov 12, 2013·Hormones and Behavior·Panida LoutchanwootHubertus Jarry
Aug 31, 2012·Drug and Chemical Toxicology·Bo XuXiao-Hai Wang
Dec 17, 2009·Hormones and Behavior·Karla S FrohmaderLique M Coolen
Jun 15, 2013·Psychoneuroendocrinology·Brittney M CoxCarmela M Reichel
Nov 5, 2010·Fertility and Sterility·Megan MitchellMichelle Lane
Jun 18, 2017·Andrology·M SemetJ Perrin
Dec 20, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Dana L ShueyRonald J Gerson
May 28, 2019·Journal of Clinical Medicine·Ylenia DucaSandro La Vignera
Mar 16, 2018·Behavioural Pharmacology·Narges PachenariSaeed Semnanian
Nov 4, 2020·Reproductive Sciences·Zahra BashiriMorteza Koruji
Jul 1, 2020·Cold Spring Harbor Perspectives in Medicine·Fair M Vassoler, Mathieu E Wimmer

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