PMID: 8608477Mar 1, 1996Paper

Chronic oral etoposide and tamoxifen in the treatment of far-advanced hepatocellular carcinoma

Cancer
A L ChengD S Chen

Abstract

Hepatocellular carcinoma (HCC) is a chemoresistant tumor that frequently expresses a high level of p 170 glycoprotein of the multidrug-resistance (MDR) gene. Preliminary data suggested that VP-16 showed modest activity in HCC. Recently, schedule-dependent cytotoxicity of VP-16 has been demonstrated. In this study, we tested the therapeutic efficacy of chronic oral VP-16 plus tamoxifen, a potential MDR-reversing agent, in patients with far-advanced HCC. A prospective single-arm study was conducted in the National Taiwan University Hospital. To be eligible, patients must have had unresectable and non-embolizable HCC, objectively measurable tumors, adequate hemogram with absolute granulocyte count greater than or equal to 2,000/mm3, and platelet count greater than or equal to 1x10 (5)/mm3, total serum bilirubin less than or equal to 3.0 mg/dl, age less than or equal to 75 years, and a Karnofsky performance status of greater then or equal to 50%. The treatment included VP-16 (Bristol-Myers-Squibb, Princeton, NJ), 50 mg/m2/day, orally, Days 1 to 21, and tamoxifen (Pharmachemie B.V. Haarlem, Netherlands), 40 mg/day, orally, Days 1 to 21; repeated every 5 weeks. Between December 1990 and December 1993, a total of 33 patients were enro...Continue Reading

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Citations

Dec 8, 2009·Current Problems in Surgery·Charles H ChaSharon M Weber
Dec 29, 1998·Human Pathology·C CohenP B DeRose
Jun 16, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anna K NowakMichael Findlay
Feb 24, 2001·Clinics in Liver Disease·A Aguayo, Y Z Patt
May 13, 2015·Biochimica Et Biophysica Acta·Samy A F Morad, Myles C Cabot
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Jan 6, 2001·Arquivos De Gastroenterologia·V P Conte

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