Chronic Osteomyelitis - Bacterial Flora, Antibiotic Sensitivity and Treatment Challenges

The Open Orthopaedics Journal
Kuzma Jerzy, Hombhanje Francis

Abstract

Chronic osteomyelitis is a catastrophic sequel of delayed diagnosis of acute osteomyelitis. The objectives of the study were to determine bacterial flora and antibiotic sensitivity, and to evaluate the outcome of an aggressive surgical approach to chronic osteomyelitis. This is a single surgeon, prospective cohort study on 30 consecutive patients with clinically and radiologically diagnosed chronic osteomyelitis presented to a hospital. We prospectively recorded demographic, clinical, radiological features, treatment protocol, microbiologic results of culture and sensitivity. The main treatment outcome measures were clinical signs of eradication of infection. Microbiologic results showed that Gram-negative and mixed flora accounts for more than half of chronic osteomyelitis cases while Staphylococcus aureus was a dominating single pathogen (39%). We detected a high resistance rate to common antibiotics, e.g. 83% of S. aureus isolates were resistant to oxacillin (MRSA). The mean duration of bone infection was 4.2 years (3 months to 30 years) and the mean number of operations was 1.5 (1-5) . The mean follow-up was 15 months (12-18 months). Infection was eradicated in 95% (21 out of 22) treated by a single procedure and in all pat...Continue Reading

References

Dec 17, 1998·Acta Orthopaedica Scandinavica·G H WalenkampM de Leeuw
Apr 2, 1999·Clinical Orthopaedics and Related Research·J T MaderJ H Calhoun
May 9, 2001·The Journal of Bone and Joint Surgery. British Volume·A H SimpsonJ M Latham
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl L NelsonKeith M Olsen
Oct 29, 2002·Journal of Orthopaedic Surgery·Steven Gitelis, Gregory T Brebach
Jun 5, 2003·Clinical Orthopaedics and Related Research·Joseph BorrelliWilliam M Ricci
Dec 17, 2003·Journal of Pediatric Orthopedics·S Austin YearganKent A Reinker
Oct 7, 2004·The Journal of Bone and Joint Surgery. American Volume·Luca LazzariniJason H Calhoun
Jun 2, 2007·Orthopedics·Mohammed Al-MaiyahRhidian L Morgan-Jones
Dec 18, 2007·FEMS Immunology and Medical Microbiology·Rebecca A BradyMark E Shirtliff
May 20, 2008·Acta Orthopaedica·Konstantinos AnagnostakosJens Kelm
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Michael S TimmersGerrolt N Jukema
Aug 28, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christine M StanleyTitus Beyeza
Sep 10, 2010·Journal of Paediatrics and Child Health·Annaleise R Howard-Jones, David Isaacs
Feb 15, 2011·International Orthopaedics·Thierry Rod-FleuryIlker Uçkay
Dec 14, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad Spellberg, Benjamin A Lipsky
Apr 2, 2013·Clinical Orthopaedics and Related Research·Antonia F ChenAndrew R Evans
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Rupnarayan BhattacharyaDebabrata Basu
Dec 18, 2013·Archives of Orthopaedic and Trauma Surgery·Sâra AytaçThorsten Guehring
Sep 6, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Chidambaram SoundrapandianDebebrata Basu
Oct 18, 2014·African Journal of Paediatric Surgery : AJPS·Reiner Wirbel, Karl Hermans
Sep 2, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Surajit MistryMathew Joy
Oct 4, 2016·Biotechnology Advances·Samit Kumar NandiBiswanath Kundu

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Citations

Dec 5, 2019·Cell Proliferation·Minyue BaoLing Ye
May 19, 2020·Journal of Biomedical Materials Research. Part a·Rodrigo L M S OliveiraEliandra de Sousa Trichês
Nov 28, 2020·Klinicheskaia laboratornaia diagnostika·I V ShipitsynaD S Leonchuk

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