Chronic osteomyelitis. The effect of the extent of surgical resection on infection-free survival

The Journal of Bone and Joint Surgery. British Volume
A H SimpsonJ M Latham

Abstract

We studied prospectively a consecutive series of 50 patients with chronic osteomyelitis. Patients were allocated to the following treatment groups: 1) wide resection, with a clearance margin of 5 mm or more; 2) marginal resection, with a clearance margin of less than 5 mm; and 3) intralesional biopsy, with debulking of the infected area. All patients had a course of antibiotics, intravenously for six weeks followed by orally for a further six weeks. No patients in group 1 had recurrence. In patients treated by marginal resection (group 2), 8 of 29 (28%) had recurrence. All patients who had debulking had a recurrence within one year of surgery. We performed a survival analysis to determine the time of the recurrence of infection. In group 2 there was a higher rate of recurrence in type-B hosts (p < 0.05); no type-A hosts had recurrence. This information is of use in planning surgery for chronic osteomyelitis.

Citations

Oct 29, 2015·BioMed Research International·Marcin K Wasko, Rafal Kaminski
Oct 7, 2004·The Journal of Bone and Joint Surgery. American Volume·Luca LazzariniJason H Calhoun
Apr 20, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C DumontK M Stürmer
Feb 27, 2008·Pharmaceutical Development and Technology·Franca FerrariGiampiero Bettinetti
Jan 14, 2011·Plastic and Reconstructive Surgery·George Cierny
May 16, 2013·Orthopedics·Julia Sanders, Cyril Mauffrey
Sep 18, 2014·Clinical Orthopaedics and Related Research·Derek OverstreetRyan McLemore
Dec 7, 2014·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·M E HakeC Mauffrey
Jul 17, 2003·Pediatric Case Reviews·John M Flynn, Samir Mehta
Jun 2, 2007·The Journal of Bone and Joint Surgery. British Volume·L Klenerman
Sep 10, 2013·The Cochrane Database of Systematic Reviews·Lucieni O Conterno, Marilia D Turchi
Sep 1, 2005·Der Unfallchirurg·S RammeltH Zwipp
May 20, 2008·Acta Orthopaedica·Jyri K KoortHannu T Aro
Aug 6, 2013·Diabetes, Obesity & Metabolism·I UçkayB A Lipsky
Mar 30, 2011·The International Journal of Lower Extremity Wounds·Javier Aragón-Sánchez
Jul 31, 2012·Current Infectious Disease Reports·Ilker UçkayDaniel Lew
Apr 5, 2015·Strategies in Trauma and Limb Reconstruction·Leonard Charles Marais, Nando Ferreira
Jan 15, 2014·Orthopedics·George Cierny
May 15, 2018·The Open Orthopaedics Journal·Kuzma Jerzy, Hombhanje Francis
Oct 11, 2016·British Journal of Hospital Medicine·Hussein TakiAlan Norrish
Jan 26, 2012·Der Unfallchirurg·B Schmidt-RohlfingH C Pape
Nov 9, 2012·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Massimo FranceschiniSebastian Vogt
Mar 7, 2014·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·D Behrendt, C Josten
Apr 8, 2014·Tropical Medicine & International Health : TM & IH·Marco BaldanKenneth G Barrand
Jan 18, 2012·Journal of Orthopaedic Trauma·Rasheed M FakriPatrick Hérard
Oct 16, 2003·The Journal of Arthroplasty·David G NazarianRobert E Booth
Jul 28, 2004·Lancet·Daniel P Lew, Francis A Waldvogel
Apr 21, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Luca LazzariniJon T Mader
Jul 7, 2007·Clinics in Podiatric Medicine and Surgery·Robert G FrykbergThomas Zgonis
Feb 24, 2010·Injury·Konstantinos N MalizosDionysios Paridis
May 18, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rachid HaidarBisharah Atiyeh
Aug 5, 2010·Foot and Ankle Clinics·Daniel J Cuttica, Terrence M Philbin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.