Chronic pain and comorbid mental health conditions: independent associations of posttraumatic stress disorder and depression with pain, disability, and quality of life

Journal of Behavioral Medicine
Samantha D OutcaltMatthew J Bair

Abstract

Both posttraumatic stress disorder (PTSD) and depression are highly comorbid with chronic pain and have deleterious effects on pain and treatment outcomes, but the nature of the relationships among chronic pain, PTSD, and depression has not been fully elucidated. This study examined 250 Veterans Affairs primary care patients with moderate to severe chronic musculoskeletal pain who participated in a randomized controlled pain treatment trial. Baseline data were analyzed to examine the independent associations of PTSD and major depression with multiple domains of pain, psychological status, quality of life, and disability. PTSD was strongly associated with these variables and in multivariate models, PTSD and major depression each had strong independent associations with these domains. PTSD demonstrated similar relationships as major depression with psychological, quality of life, and disability outcomes and significant but somewhat smaller associations with pain. Because PTSD and major depression have independent negative associations with pain, psychological status, quality of life, and disability, it is important for clinicians to recognize and treat both mental disorders in patients with chronic pain.

Associated Clinical Trials

References

Aug 1, 1991·Pain·J A HaythornthwaiteR D Kerns
Mar 1, 1989·Medical Care·L E KazisR F Meenan
Dec 1, 1983·Journal of Health and Social Behavior·S CohenR Mermelstein
Aug 1, 1996·Behaviour Research and Therapy·E B BlanchardC A Forneris
Mar 1, 1997·The Clinical Journal of Pain·M E RobinsonF J Keefe
Apr 29, 1998·Journal of Anxiety Disorders·E B BlanchardA E Taylor
Aug 11, 2001·Clinical Psychology Review·T J Sharp, A G Harvey
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Mar 27, 2002·Psychosomatic Medicine·Kurt KroenkeJanet B W Williams
Jan 30, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Gordon J G AsmundsonJoel Katz
Nov 12, 2003·Archives of Internal Medicine·Matthew J BairKurt Kroenke
Apr 15, 2004·Journal of Rehabilitation Research and Development·John D OtisRobert D Kerns
Nov 6, 2004·Journal of Clinical Epidemiology·Anthony J PerkinsChristopher M Callahan
May 24, 2006·Archives of Internal Medicine·Robert L SpitzerBernd Löwe
Nov 1, 2006·Journal of Traumatic Stress·Joaquin PoundjaAlain Brunet
Mar 18, 2008·The Journal of Pain : Official Journal of the American Pain Society·Randy S RothRachel Bates
Oct 13, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·John D OtisErica Scioli
May 17, 2011·Journal of Pain and Symptom Management·Hsiao-Lan WangSusan M Rawl
Jun 18, 2011·The Journal of Pain : Official Journal of the American Pain Society·Kurt KroenkeWanzhu Tu
Jul 19, 2011·Psychological Trauma : Theory, Research, Practice and Policy·J Gayle Beck, Joshua D Clapp
Dec 12, 2012·Contemporary Clinical Trials·Kurt KroenkeZhangsheng Yu
Jul 3, 2013·Pain Research and Treatment·Michelle A BoscoMichael E Clark
Aug 9, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jennifer Jane RunnalsPatrick S Calhoun
Aug 22, 2014·Journal of Rehabilitation Research and Development·Samantha D OutcaltMatthew J Bair

❮ Previous
Next ❯

Citations

Dec 2, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Michelle A AndersonDavid C Whitcomb
Aug 13, 2015·Best Practice & Research. Clinical Rheumatology·Leslie J Crofford
Apr 7, 2017·The Journal of Trauma and Acute Care Surgery·Avi BenovElon Glassberg
May 25, 2018·International Journal of Palliative Nursing·Sheran M Simo, Debra Siela
Oct 19, 2017·European Journal of Psychotraumatology·J SiqvelandE Hauff
Mar 15, 2019·Journal of Correctional Health Care : the Official Journal of the National Commission on Correctional Health Care·Kirsten E SmithT K Logan
Jun 14, 2019·PLoS Genetics·Keira J A JohnstonDaniel J Smith
Jun 25, 2019·Physiotherapy Theory and Practice·Timothy M BenedictAdriaan Louw
Oct 28, 2019·Pain Practice : the Official Journal of World Institute of Pain·Dokyoung S YouSean C Mackey
Jan 4, 2020·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Elena BileviciusRenée El-Gabalawy
Dec 15, 2019·BMC Psychiatry·Richard F ArmentaUNKNOWN Millennium Cohort Study Team
Aug 31, 2019·Health Communication·Chelsea R Chapman, Wayne A Beach
Jan 4, 2018·Journal of Interpersonal Violence·Julian D FordBiree Andemariam
Feb 20, 2020·Journal of Behavioral Medicine·Michael J ZvolenskyJafar Bakhshaie
Sep 16, 2020·Cellular and Molecular Neurobiology·Yong Zhang, Kelly M Standifer
Aug 25, 2020·Proceedings. Mathematical, Physical, and Engineering Sciences·Aaron F Alexander-BlochCynthia A Brandt
May 5, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ariel M BariaChristine Miaskowski
Mar 9, 2019·The Psychiatric Quarterly·Kathryn Hefner, Robert Rosenheck
Jun 6, 2019·European Journal of Psychotraumatology·Lisa M McAndrewKaren S Quigley
Nov 2, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Manasi M MittintyLiesbet Goubert
Nov 30, 2019·Current Pain and Headache Reports·Shelley Kind, John D Otis
Sep 26, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Emre UmucuCarolina Valencia
Jan 30, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Andrea GillmanAjay D Wasan
Dec 12, 2020·Frontiers in Psychiatry·Claudia CarmassiLiliana Dell'Osso
Feb 6, 2020·Psychiatry Research·Matthew S HerbertSonya B Norman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

© 2021 Meta ULC. All rights reserved