Chronic pain in hypermobility syndrome and Ehlers-Danlos syndrome (hypermobility type): it is a challenge

Journal of Pain Research
Mark C ScheperRaoul Hh Engelbert

Abstract

Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical sign that is frequently present in hereditary diseases of the connective tissue, such as the Marfan syndrome, osteogenesis imperfecta, and the Ehlers-Danlos syndrome. However, within the Ehlers-Danlos spectrum, a similar subcategory of patients having similar clinical features as HMS but lacking a specific genetic profile was identified: Ehlers-Danlos syndrome hypermobility type (EDS-HT). Researchers and clinicians have struggled for decades with the highly diverse clinical presentation within the HMS and EDS-HT phenotypes (Challenge 1) and the lack of understanding of the pathological mechanisms that underlie the development of pain and its persistence (Challenge 2). In addition, within the HMS/EDS-HT phenotype, there is a high prevalence of psychosocial factors, which again presents a difficult issue that needs to be addressed (Challenge 3). Despite recent scientific advances, many obstacles for clinical care and ...Continue Reading

Citations

Feb 12, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Pradeep ChopraClair Francomano
Feb 2, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Brad TinkleHoward Levy
Mar 18, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Raoul H H EngelbertJane V Simmonds
May 29, 2018·European Journal of Pain : EJP·M-A FitzcharlesW Häuser
Jan 10, 2019·American Journal of Medical Genetics. Part a·Jane R SchubartClair Francomano
Mar 12, 2019·American Journal of Medical Genetics. Part a·Chiara LeoniGiuseppe Zampino
May 8, 2019·Disability and Rehabilitation·Larissa KalischCarolina Baeza-Velasco
Oct 16, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Heléne E K SundelinJonas F Ludvigsson
Jun 4, 2020·BMC Musculoskeletal Disorders·Vadood Javadi ParvanehReza Shiari
Feb 3, 2018·Pain Reports·Winfried HäuserMary-Ann Fitzcharles
Sep 25, 2020·Children·Estée C H FeldmanRachel Neff Greenley
Aug 31, 2020·Scandinavian Journal of Pain·Thijs van MeulenbroekJeanine A Verbunt
Jan 19, 2021·Proceedings·Bo SongJohn Harrell

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