Chronic pain induces generalized enhancement of aversion

ELife
Qiaosheng ZhangJing Wang

Abstract

A hallmark feature of chronic pain is its ability to impact other sensory and affective experiences. It is notably associated with hypersensitivity at the site of tissue injury. It is less clear, however, if chronic pain can also induce a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs. Here, we showed that chronic pain in one limb in rats increased the aversive response to acute pain stimuli in the opposite limb, as assessed by conditioned place aversion. Interestingly, neural activities in the anterior cingulate cortex (ACC) correlated with noxious intensities, and optogenetic modulation of ACC neurons showed bidirectional control of the aversive response to acute pain. Chronic pain, however, altered acute pain intensity representation in the ACC to increase the aversive response to noxious stimuli at anatomically unrelated sites. Thus, chronic pain can disrupt cortical circuitry to enhance the aversive experience in a generalized anatomically nonspecific manner.

References

Nov 1, 1992·Journal of Neurophysiology·R W Sikes, B A Vogt
Jan 1, 1995·Somatosensory & Motor Research·J D TalbotG H Duncan
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Nov 21, 1996·Nature·A D CraigM C Bushnell
May 13, 1999·Nature Neuroscience·W D HutchisonJ O Dostrovsky
Oct 9, 1999·Journal of Neurophysiology·R C CoghillM J Iadarola
Mar 29, 2001·Neuroscience Research·T KoyamaA Mikami
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·J P JohansenB H Manning
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·George BushBruce R Rosen
Apr 23, 2003·Brain Research·Jen-Chuang KungBai-Chuang Shyu
Jul 5, 2003·Journal of Neurophysiology·I E T de AraujoP Hobden
Aug 1, 1964·Journal of Comparative and Physiological Psychology·J F LUBAR
Mar 9, 2004·Nature Neuroscience·Joshua P Johansen, Howard L Fields
Jun 2, 2005·Journal of Neurophysiology·Koichi IwataJunichi Kitagawa
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Long-Jun WuMin Zhuo
May 16, 2006·Lancet·Henrik KehletClifford J Woolf
Jul 17, 2007·Journal of Pain and Symptom Management·Ian KudelSrinivasa N Raja
Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alban Latremoliere, Clifford J Woolf
Sep 29, 2009·Nature Neuroscience·Tamara KingFrank Porreca
Oct 20, 2009·Cell·Allan I BasbaumDavid Julius
Apr 2, 2010·Journal of Neurophysiology·Bai-Chuang ShyuBrent A Vogt
Aug 28, 2010·The Journal of Bone and Joint Surgery. British Volume·C E H ScottL C Biant
Jun 19, 2012·Neuroscience Letters·Petra Schweinhardt, M Catherine Bushnell
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Edita NavratilovaFrank Porreca
Apr 12, 2013·The New England Journal of Medicine·Tor D WagerEthan Kross
May 21, 2013·Annals of Neurology·Milena De FeliceFrank Porreca
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ihab DaouPhilippe Séguéla
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yossef GofferJing Wang
Jul 30, 2014·Analytica Chimica Acta·J M Andrade, M G Estévez-Pérez
Dec 1, 2014·Biological Psychiatry·Florent BarthasIpek Yalcin

❮ Previous
Next ❯

Citations

Jun 22, 2018·The Clinical Journal of Pain·Lisa V Doan, Jing Wang
Jan 17, 2020·Journal of Neural Engineering·Xinling GuoZhe Sage Chen
Aug 29, 2018·Frontiers in Cellular Neuroscience·Haocheng ZhouJing Wang
Sep 13, 2018·Journal of Computational Neuroscience·Zhengdong XiaoZhe Chen
May 8, 2018·Frontiers in Cellular Neuroscience·Ruohe ZhaoGuang Yang
May 31, 2018·Scientific Reports·Qiaosheng ZhangJing Wang
May 21, 2019·Frontiers in Cellular Neuroscience·Zhengdong XiaoZhe Sage Chen
Oct 15, 2019·Psychosomatic Medicine·Louise Urien, Jing Wang
Mar 20, 2019·Neuroscience and Biobehavioral Reviews·Anke Tappe-TheodorMichael M Morgan
Mar 30, 2020·Current Biology : CB·Amrita SinghJing Wang
May 3, 2018·Cell Reports·Jahrane DaleJing Wang
Aug 6, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patrick H FinanKelly E Dunn
Jun 16, 2021·Nature Reviews. Neuroscience·Linette Liqi Tan, Rohini Kuner
Jun 23, 2021·Nature Biomedical Engineering·Qiaosheng ZhangJing Wang
Sep 11, 2021·Journal of Molecular Neuroscience : MN·Hyeong Cheol Moon, Young Seok Park
Oct 6, 2021·Journal of Neural Engineering·Zhe Sage Chen

❮ Previous
Next ❯

Software Mentioned

Open Ephys
GraphPad Prism
AnyMaze
MATLAB Machine Learning Toolbox
Any
maze
MATLAB
Offline Sorter
GraphPad

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.