PMID: 11915071Mar 27, 2002Paper

Chronic pain with beneficial response to electroconvulsive therapy and regional cerebral blood flow changes assessed by single photon emission computed tomography

Regional Anesthesia and Pain Medicine
Sei FukuiShuichi Nosaka

Abstract

Recent neuroimaging studies suggested that chronic neuropathic pain may be largely sustained by a complex neuronal network involving the thalamus. Although recent studies have demonstrated the efficacy of electroconvulsive therapy (ECT) in the treatment of a variety of types of chronic neuropathic pain, the effects of ECT on regional cerebral blood flow (rCBF) have not been studied. We present a 50-year-old female postsurgical chronic pain patient whose pain had failed to respond to standard pain treatment, but was resolved by ECT. To investigate the potential role of rCBF in ECT's analgesic effect, we measured significant changes in the rCBF in the thalamus before and after a course of bilateral ECT using technetium-99m ethyl cysteinate dimer (99mTc-ECD) single photon emission computed tomography (SPECT). 99mTc-ECD SPECT showed a significant bilateral decrease in the thalamus on the side of the pain, and this decreased rCBF in the thalamus increased after ECT. The results from the SPECT suggest that ECT increases abnormally decreased thalamus activity in chronic neuropathic pain.

Citations

Mar 5, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ajay D WasanMichael R Clark
Nov 25, 2016·Pain Management·Anna Borisovskaya, Jay Alan Augsburger
May 6, 2005·The International Journal of Lower Extremity Wounds·Jane F Hazelgrove, Peter D Rogers
Jan 24, 2007·Journal of Psychiatric Practice·Arash MowlaJack M Gorman

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