PMID: 9548677Apr 21, 1998Paper

Chronic pancreatitis: functional testing

Pancreas
K OchiT Seno

Abstract

This article reviews the evolution of functional testing of the pancreas in Japan for the diagnosis and treatment of chronic pancreatitis (CP), contrasting the pre- with the postsecretin test (S test) era. In the pre-S test era, the diagnosis was based on symptoms, clinical findings, fasting serum diastase levels, and the vagostigmin- and ether-stimulation test unless morphologic evidence was available. The S test and CCK-pancreozymin (PZ) test (PS test) were introduced into Japan around 1963 and have been used as the gold standard of the exocrine pancreatic-function test. Through a series of attempts at standardization in 1971, 1985, and 1987, the method was standardized to collect duodenal juice for 60 min through a double- or triple-lumen tube after a bolus or during a continuous i.v. injection of secretin (100 U). The S test, however, is an invasive and cumbersome procedure. As a result, N-benzoyl-L-tyrosal-p-aminobenzoic acid (BT-PABA) testing and fecal chymotrypsin testing were introduced into Japan in the middle and late 1970s, respectively. Although simple and noninvasive, these two methods were found have lower sensitivity and specificity than the conventional S test. These two methods, therefore, are presently used mo...Continue Reading

Citations

Feb 20, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S MaartenseA A M Masclee
Feb 26, 2011·Journal of Gastroenterology and Hepatology·Rungsun Rerknimitr
Jun 10, 2009·Best Practice & Research. Clinical Gastroenterology·Jutta KellerPeter Layer
Dec 29, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen, O B de Muckadell
Mar 12, 2020·Japanese Journal of Radiology·Reiji SugitaYutaka Noda
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·R S Chowdhury, C E Forsmark

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