Chronic passive exposure to aggression decreases D2 and 5-HT 1B receptor densities

Physiology & Behavior
Hideo SuzukiLouis R Lucas

Abstract

It has been recently reported that passive exposure to aggression induces aggressive behavior in a rodent model. However, it remains unclear whether this response is correlated with neurochemical changes that correspond either to stress-induced aggression or non-stressed, learned aggression. Stress-induced aggression has been shown to result in increased brain dopamine D(2) receptor and serum corticosterone levels. In contrast, learned aggression is probably associated with reward deficiency syndrome, characterized by low dopamine D(2) receptor levels, without stress effects (i.e., high corticosterone levels). We hypothesized that chronic passive exposure to aggression would produce learned aggression, represented by low levels of dopamine D(2) receptor binding but normal levels of stress hormone. The present study additionally focused on serum testosterone and serotonin 5-HT(1B) receptor density that has been associated with aggression/reward circuits. Hormonal results indicated that there were no differences between the "observer" rats that had been passively exposed to aggression and non-aggression for 10 min/day for 23 consecutive days. However, receptor binding autoradiography identified lower densities of dopamine D(2) re...Continue Reading

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Citations

Feb 5, 2015·Cognitive, Affective & Behavioral Neuroscience·Hideo Suzuki, Louis R Lucas

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