PMID: 15223818Jun 30, 2004Paper

Chronic placental insufficiency affects retinal development in the guinea pig

Investigative Ophthalmology & Visual Science
Michelle LoeligerS Rees

Abstract

Very low birth weight (VLBW) and fetal growth restriction are associated with increased risks of long-term visual impairments, including alterations to contrast sensitivity, a parameter mediated in part by dopaminergic amacrine cells. This study was conducted to determine whether chronic placental insufficiency (CPI), sufficient to cause growth restriction, results in neurochemical alterations to retinal interneurons, specifically amacrine and horizontal cell populations near term. CPI was induced just before midgestation (term approximately 67 days of gestation, dg) in guinea pigs through unilateral ligation of the uterine artery. Growth-restricted (GR, n = 32) and control (n = 29) fetuses were euthanized at 60 dg and retinas prepared for analysis of amacrine cell populations by using antibodies to calbindin, calretinin, cholineacetyltransferase (ChAT), gamma-amino-butyric acid (GABA), dopamine beta-hydroxylase (D beta H), tyrosine hydroxylase (TH, dopaminergic), and NADPH-diaphorase histochemistry (nitrergic). Calbindin immunoreactivity (IR) was also used to identify horizontal cells. HPLC was used to assess concentrations of catecholamines and Western blot analysis to detect total TH levels. In GR compared with control fetus...Continue Reading

Citations

Feb 14, 2009·Cell and Tissue Research·Kathryn MunroMary Tolcos
Nov 17, 2010·Hypertension·Xiaozhong WenStephen L Buka
Apr 24, 2013·PloS One·Stephane L BourqueYves Sauvé
Sep 18, 2012·Progress in Retinal and Eye Research·Heidrun KuhrtHamid R Noori
Aug 27, 2011·Experimental Neurology·Mary TolcosSandra Rees
Apr 13, 2010·Progress in Retinal and Eye Research·Erica L FletcherJennifer L Wilkinson-Berka
Jul 17, 2009·Veterinary Ophthalmology·Thamara A CafaroHoracio M Serra
Apr 30, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ozgül SalihoğluAsiye Nuhoğlu
Nov 3, 2009·The Journal of Comparative Neurology·Laura E DownieErica L Fletcher
Jan 18, 2005·Experimental Eye Research·Michelle Loeliger, Sandra Rees
May 26, 2006·Vision Research·Xiangtian ZhouFan Lu
Feb 27, 2007·Endocrine Reviews·Paul SaengerEdward O Reiter
Jun 28, 2011·Toxicology and Applied Pharmacology·Donald A FoxJames P O'Callaghan

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