Chronic prolonged hyponatremia and risk of hip fracture in elderly patients with chronic kidney disease

Bone
Sagar U NigwekarJuan Carlos Ayus

Abstract

Chronic prolonged hyponatremia (CPH) is a risk factor for hip fracture in the general population. Whether CPH increases hip fracture risk in chronic kidney disease (CKD) patients is unknown. Case-control study in patients over 60 years of age with stage 3 or greater CKD. Patients who had a hip fracture were referred to as cases (n = 1236) and controls had no hip fracture (n = 4515). Patients were classified as having CPH if serum sodium was <135 mEq/L on at least two occasions separated by a minimum of 90 days prior to the diagnosis of hip fracture (cases) or at any time during the study period (controls). Conditional logistic regression models were used to test the association between CPH and hip fracture. Analyses were conducted for patients with and without osteoporosis and falls and for patients with age >70 years versus ≤70 years. CPH was present in 21% of cases and 10% of controls (p < 0.001; sodium level: 131-134 mEq/L). In univariate logistic regression analysis, CPH was associated with higher odds of hip fracture (odds ratio [OR] 2.44, (95% [CI] 2.07-2.89). In a multivariate model adjusted for comorbidities, medications and laboratory parameters CPH association with higher odds of Hip fracture was attenuated but remain...Continue Reading

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Citations

Feb 15, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tatiane VilacaRichard Eastell
Nov 7, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J C Ayus, A L Negri
Feb 17, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Juan Carlos AyusArmando Luis Negri

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