Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters

Journal of Occupational Health
Akiyo TanakaYutaka Kiyohara

Abstract

The aim of this study was to clarify the chronic toxicological effects of indium-tin oxide (ITO) and indium oxide (In(2)O(3)) on laboratory animals. Male Syrian golden hamsters were intratracheally administered 3 mg/kg or 6 mg/kg of ITO particles, or 2.7 mg/kg or 5.4 mg/kg of In(2)O(3) particles, containing 2.2 mg/kg or 4.5 mg/kg of indium, twice a week, for 8 wk. Control hamsters were given vehicle of distilled water only. The hamsters were euthanized serially up to 78 wk after the final instillation and the toxicological effects were determined. Body weight gain was significantly suppressed in the ITO 6 mg/kg-treated hamsters compared with the control group, but not in the ITO 3 mg/kg-treated or In(2)O(3)-treated hamsters. Relative lung weights among all the indium-treated groups were significantly increased compared to that in the control group throughout the observation period. The serum indium concentration among all the indium-treated groups gradually increased up to the end of the observation period. Histopathologically, foci of slight to severe pulmonary inflammatory response with diffuse alveolar or bronchiolar cell hyperplasia, expansion of the alveolar spaces and interstitial fibrotic proliferation were present in al...Continue Reading

References

Oct 19, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·B C GottschlingA Nyska
Dec 4, 2003·Journal of Occupational Health·Toshiaki HommaMiyuki Hirata
Dec 17, 2003·Journal of Occupational Health·Akiyo TanakaMinoru Omura
Jan 11, 2005·The European Respiratory Journal·S HommaK Yoshimura
Oct 20, 2006·The European Respiratory Journal·T ChonanK Omae

❮ Previous
Next ❯

Citations

Aug 13, 2011·International Archives of Occupational and Environmental Health·Hung-Hsin LiuHsiu-Ling Chen
Nov 8, 2013·Journal of Occupational and Environmental Hygiene·Cynthia J HinesJames A Deddens
Jul 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·William M GwinnDaniel L Morgan
Dec 31, 2011·Chest·Kristin J CummingsKathleen Kreiss
Mar 23, 2011·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Apr 8, 2011·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Jan 15, 2011·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Oct 9, 2014·Annals of the American Thoracic Society·Kristin J CummingsKathleen Kreiss
Oct 17, 2015·Journal of Applied Toxicology : JAT·Melissa A BaddingStephen S Leonard
Jul 21, 2011·Toxicology Letters·Perrine HoetDominique Lison
May 12, 2015·Journal of Occupational Health·Makiko NakanoKazuyuki Omae
Dec 21, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·William M GwinnDaniel L Morgan
Dec 18, 2013·Cytotechnology·İbrahim Hakkı CiğerciMuhsin Konuk
Sep 12, 2014·Journal of Toxicology and Environmental Health. Part a·Melissa A BaddingStephen S Leonard
May 25, 2016·American Journal of Industrial Medicine·Kristin J CummingsKathleen Kreiss
Jun 17, 2016·Inhalation Toxicology·Shuhei NoguchiNarufumi Suganuma
Mar 22, 2019·Journal of Occupational Health·Makiko NakanoMiyuki Hirata
Dec 17, 2016·Journal of Occupational Health·Naw Awn JpNarufumi Suganuma
Jun 10, 2020·International Archives of Occupational and Environmental Health·Jianping YangJing Feng
May 31, 2013·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiyo Tanaka, Miyuki Hirata
Oct 4, 2016·Current Environmental Health Reports·Sarah Jane O White, James P Shine
Feb 16, 2021·International Journal of Hygiene and Environmental Health·Yuan-Ting HsuSaou-Hsing Liou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved