Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex

Journal of Neurophysiology
Bryan J BlackStuart F Cogan

Abstract

Multisite implantable electrode arrays serve as a tool to understand cortical network connectivity and plasticity. Furthermore, they enable electrical stimulation to drive plasticity, study motor/sensory mapping, or provide network input for controlling brain-computer interfaces. Neurobehavioral rodent models are prevalent in studies of motor cortex injury and recovery as well as restoration of auditory/visual cues due to their relatively low cost and ease of training. Therefore, it is important to understand the chronic performance of relevant electrode arrays in rodent models. In this report, we evaluate the chronic recording and electrochemical performance of 16-channel Utah electrode arrays, the current state-of-the-art in pre-/clinical cortical recording and stimulation, in rat motor cortex over a period of 6 mo. The single-unit active electrode yield decreased from 52.8 ± 10.0 ( week 1) to 13.4 ± 5.1% ( week 24). Similarly, the total number of single units recorded on all electrodes across all arrays decreased from 106 to 15 over the same time period. Parallel measurements of electrochemical impedance spectra and cathodic charge storage capacity exhibited significant changes in electrochemical characteristics consistent w...Continue Reading

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Citations

Jun 11, 2020·Journal of Neural Engineering·Jessica D FalconeHarbaljit S Sohal
May 10, 2019·Frontiers in Neuroscience·Aparna NambiarMartin Han
Sep 19, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bitan ChakrabortyStuart F Cogan
Sep 19, 2020·Journal of Neural Engineering·Nicholas F NoltaMartin Han
Oct 10, 2020·Biosensors & Bioelectronics·Atefeh GhazaviStuart F Cogan
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Weiyang YangWen Li
Apr 30, 2021·Frontiers in Neuroscience·Maryam HejaziDavid J Garrett
Nov 20, 2021·Journal of Neural Engineering·Jae-Won JangSohee Kim
Dec 1, 2021·Journal of Neural Engineering·Caleb SponheimNicholas G Hatsopoulos

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Methods Mentioned

BETA
delamination

Software Mentioned

Omniplex
NeuroExplorer
OriginPro
Plexon Sorter
MATLAB
PlexControl

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