Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment

Current Osteoporosis Reports
S R HofmannC M Hedrich

Abstract

Chronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO. Though the exact molecular pathophysiology of CNO/CRMO remains somewhat elusive, it appears likely that variable defects in the TLR4/MAPK/inflammasome signaling cascade result in an imbalance between pro- and anti-inflammatory cytokine expressions in monocytes from CNO/CRMO patients. In this context, we present previously unpublished data on cytokine and chemokine expression in monocytes and tissues. CNO/CRMO is an autoinflammatory bone disorder resulting from imbalanced cytokine expression from innate immune cells. Though the exact molecular pathophysiology remains unclear, variable molecular defects appear to result in inflammasome activation and pro-inflammatory cytokine expression in monocytes from CNO/CRMO patients. Recent advances suggest signaling pathways and single molecules as biomarkers for CNO/CRMO as well as future treatment targets.

References

Apr 1, 1997·Skeletal Radiology·A G Jurik, N Egund
Mar 25, 2000·Bone·T A HentunenG D Roodman
Apr 26, 2002·European Journal of Human Genetics : EJHG·Astrid GollaAlfons Meindl
Jul 20, 2002·Journal of Pediatric Orthopedics·Catherine M DuffyH Kerr Graham
Oct 13, 2004·Seminars in Musculoskeletal Radiology·Anne Grethe Jurik
Jan 7, 2006·Blood·Johannes GrosseE Richard Stanley
May 15, 2007·Clinical Orthopaedics and Related Research·Hatem I El-Shanti, Polly J Ferguson
Sep 1, 2007·Current Opinion in Rheumatology·Polly J Ferguson, Hatem I El-Shanti
Nov 27, 2007·Nature Clinical Practice. Rheumatology·Hermann J GirschickHenner Morbach
Apr 1, 2009·Arthritis and Rheumatism·Annette F JanssonVolkmar Jansson
May 21, 2009·Journal of Bone and Mineral Metabolism·Tomoki Nakashima, Hiroshi Takayanagi
Jun 6, 2009·The New England Journal of Medicine·Ivona AksentijevichRaphaela Goldbach-Mansky
Jun 6, 2009·The New England Journal of Medicine·Sreelatha ReddyJames Verbsky
Jul 9, 2009·Journal of Clinical Immunology·Tomoki Nakashima, Hiroshi Takayanagi
Jul 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Geetika KhannaPolly Ferguson
Jan 21, 2010·Immunologic Research·Christian M Hedrich, Jay H Bream
Jun 30, 2010·Communicative & Integrative Biology·Sohail AhmedWah Ing Goh
Jan 18, 2011·Rheumatology International·J HamelC M Hedrich
Mar 1, 2011·Acta Paediatrica·Annette F JanssonUNKNOWN ESPED Study Group
Mar 29, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Julien WipffChantal Job-Deslandre
Jul 27, 2011·Current Opinion in Rheumatology·Marinka Twilt, Ronald M Laxer
Sep 20, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S R HofmannC M Hedrich
Feb 16, 2012·The Journal of Biological Chemistry·Martín ValdearcosMaría A Balboa
Mar 31, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S R HofmannC M Hedrich
Sep 4, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sigrun R HofmannChristian M Hedrich
Oct 17, 2012·Pediatrics·Arturo BorzutzkyRobert P Sundel
Oct 23, 2012·Annals of the Rheumatic Diseases·Troels HerlinPolly J Ferguson
Feb 2, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Henner MorbachHermann J Girschick
Aug 7, 2013·Current Opinion in Rheumatology·Manisha Sharma, Polly J Ferguson
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Sara M Stern, Polly J Ferguson
Dec 24, 2013·Pediatric Rheumatology Online Journal·Christian M HedrichHermann J Girschick
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·John R LukensThirumala-Devi Kanneganti
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Suzanne L CasselPolly J Ferguson
Jul 26, 2014·Pediatric Rheumatology Online Journal·Roberta ScianaroGiusi Prencipe
Sep 2, 2014·Arthritis Research & Therapy·Claire J GreenhillSimon A Jones
Oct 3, 2014·Nature·John R LukensThirumala-Devi Kanneganti
Dec 11, 2014·Annual Review of Immunology·Mihai G NeteaLeo A B Joosten
Dec 30, 2014·Arthritis & Rheumatology·J WipffC Job-Deslandre
Sep 26, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S R HofmannC M Hedrich

❮ Previous
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Citations

Jun 19, 2018·Current Opinion in Rheumatology·Allison J Cox, Polly J Ferguson
May 30, 2019·Hand : Official Journal of the American Association for Hand Surgery·Yasiru G KarunaratneDavid Graham
Jul 20, 2019·Clinical Pediatrics·Eileen C RifeAbraham Gedalia
Jul 8, 2017·Molecular and Cellular Pediatrics·Sigrun Ruth HofmannChristian Michael Hedrich
Jan 25, 2020·Journal of Dental Research·H YaharaK Yahara
Oct 28, 2019·Postgraduate Medical Journal·Hamid EshaghiMoeinadin Safavi
Nov 14, 2019·The Journal of Biological Chemistry·Tejasvi K DasariThirumala-Devi Kanneganti
Aug 14, 2018·Annals of the Rheumatic Diseases·Eldad Ben-ChetritUNKNOWN Paediatric Rheumatology International Trials Organisation (PRINTO) and the AIDs Delphi study participants
Jul 11, 2020·Rheumatology·Savvas AndronikouAthimalaipet V Ramanan
Sep 1, 2019·BMC Musculoskeletal Disorders·Joanna Świdrowska-Jaros, Elżbieta Smolewska
Oct 18, 2018·Oral and Maxillofacial Surgery·Jan RustemeyerAlexander Busch
Dec 15, 2018·Pediatric Rheumatology Online Journal·Melissa OliverUNKNOWN CARRA SVARD CRMO/CNO workgroup
May 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Koichiro AbeMartin Hrabe de Angelis
Jul 20, 2019·Pediatric Rheumatology Online Journal·Nentwich JuliaHofmann Christine
Feb 23, 2020·Journal of Clinical Medicine·Sebastian F BaumbachJan Leipe
Jul 25, 2020·Current Rheumatology Reports·Christian M HedrichHermann J Girschick
Feb 18, 2020·Pediatric Blood & Cancer·Minako SugiyamaAtsushi Manabe
Jun 12, 2020·Therapeutic Advances in Musculoskeletal Disease·Shuang LiuChen Li
Apr 19, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E RolfesT Kallinich
May 21, 2019·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Soung Min Kim, Suk Keun Lee
Jan 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Masatoshi HottaHiroyuki Yamashita
May 3, 2019·Case Reports in Rheumatology·Farhad SalehzadehSepehr Sarkhanloo
Oct 23, 2020·Modern Rheumatology Case Reports·Tessa N CampbellPaul MacMullan
Dec 29, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Toru FujisakiTatsuki Mizuochi
Mar 7, 2021·Biomolecules·Polly J Ferguson, Hatem El-Shanti
Mar 31, 2021·Pediatric Rheumatology Online Journal·Nina M de GruijterCoziana Ciurtin
Apr 20, 2021·Journal of Translational Autoimmunity·Dan Yongdong ZhaoChristian M Hedrich
Jun 19, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Cheng-Jui YangMichihiko Sone
Jun 29, 2021·The Journal of Allergy and Clinical Immunology·Miyuki TsumuraSatoshi Okada
Jul 3, 2021·Children·Aikaterini KoryllouRaffaella Carlomagno
Jul 16, 2021·Frontiers in Immunology·Jie-Jie XuJun Li
Aug 26, 2021·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Jian YangLei Peng

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Methods Mentioned

BETA
imaging techniques
biopsies
exome sequencing
biopsy
ESR

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