Chronic reduction of nitric oxide level in adult spontaneously hypertensive rats induces aortic stiffness similar to old spontaneously hypertensive rats

Journal of Vascular Research
Marc IsabelleTony J Verbeuren

Abstract

Age and hypertension are two major determinants of arterial stiffness, as well as endothelial dysfunction. The present study was designed to test whether a chronic reduction of endogenous nitric oxide (NO) produces arterial stiffening close to that observed in old spontaneously hypertensive rats (SHR), and also to study the effect of an acute or a chronic decrease in blood pressure (BP) on aortic distensibility. BP, aortic stiffness, endothelial dysfunction and remodelling were measured in male adult (20-week-old) SHR, in adult SHR treated with a nonspecific NO synthase inhibitor L-NAME (SHR/L-NAME) for 2 weeks, in adult SHR/L-NAME cotreated with perindopril (1 mg/kg/day) and in old SHR (55-week-old). Age-matched WKY were used as a normotensive group. Aortic endothelial dysfunction, remodelling and stiffening appeared in old SHR. Reduction of NO production in adult SHR caused similar alterations. Acute decreases in BP in SHR/L-NAME did not improve isobaric aortic distensibility but a chronic reduction of BP prevented endothelial dysfunction, aortic remodelling and aortic wall stiffening. NO reduction in adult SHR induces aortic alterations similar to those observed during aging, which supports the major role of NO in the develo...Continue Reading

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Citations

Jan 15, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Leylliane de Fátima Leal InteraminenseSaad Lahlou
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cameron G McCarthyR Clinton Webb
Mar 19, 2014·Vascular Pharmacology·Chun-Yi NgKamsiah Jaarin
May 29, 2016·Physiological Reports·George LindesayChristine Vayssettes-Courchay
Jun 11, 2018·Journal of Vascular Research·George LindesayChristine Vayssettes-Courchay
Jun 19, 2014·Journal of the American Heart Association·Gwennan AndréVincent Sauzeau
Jul 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Benard O OgolaSarah H Lindsey
Nov 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yanyan ZhangLijun Shi
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Nov 23, 2017·Frontiers in Physiology·Arthur LeloupPaul Fransen
Jul 10, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Francisco I Ramirez-PerezJaume Padilla

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