Chronic rejection: Differences and similarities in various solid organ transplants

Der Internist
H SuhlingJ H Bräsen

Abstract

In this paper, chronic rejections after transplantation of the lungs, heart, liver, and kidney are described. Chronic allograft dysfunction (CAD) plays an important role in all of these transplantations and has a significant influence on patient survival. The pathophysiological reasons for CAD varies greatly in the various organs.Chronic lung allograft dysfunction (CLAD) is the most important determinant of survival and quality of life after lung transplantation. Diagnosis is based on lung function, especially forced expiratory flow in 1 s (FEV1) decline. Prevention, early detection, and rapid treatment are extremely important. Azithromycin and extracorporeal photopheresis are commonly used for treatment because they usually positively influence the progression of lung remodeling.The expression for chronic rejection of the heart is cardiac allograft vasculopathy (CAV). Immunological and nonimmunological factors are important for its development. Due to limited therapeutic options, prevention is of utmost importance (administration of mTOR inhibitors and minimizing cardiovascular risk factors).The mid- and long-term survival rates after liver transplantation have hardly changed in recent decades, which is an indication of the di...Continue Reading

References

Jul 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·K BandoR J Duquesnoy
Mar 20, 1999·Transplantation Proceedings·M J MihatschF Gudat
Sep 27, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H RegeleG A Böhmig
Feb 6, 2002·Zeitschrift für Kardiologie·A Haverich, K Kallenbach
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Jan 18, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John M CostelloElfriede Pahl
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bela Ivanyi
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Seiichirou ShishidoAkira Hasegawa
May 14, 2003·Circulation·Donna ManciniAndrew R Marks
Aug 29, 2003·The New England Journal of Medicine·Robin K Avery
Aug 29, 2003·The New England Journal of Medicine·Howard J EisenUNKNOWN RAD B253 Study Group
Apr 13, 2004·Current Opinion in Cardiology·Sean P Pinney, Donna Mancini
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alida L P CaforioGino Gerosa
Jul 16, 2004·Kidney International·David C KluthAndrew J Rees
Sep 22, 2005·Nature Reviews. Immunology·Robert B Colvin, R Neal Smith
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon A KobashigawaLawrence Yeatman
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anthony J DemetrisFunda Yilmaz
Oct 31, 2006·Seminars in Respiratory and Critical Care Medicine·Christiane Knoop, Marc Estenne
Jan 30, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Karin M VermuelenElisabeth M TenVergert
Mar 10, 2007·American Journal of Respiratory and Critical Care Medicine·Vibha N LamaFernando J Martinez
Dec 22, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan StewartSamuel A Yousem
Jan 29, 2008·Experimental Biology and Medicine·Tatiana Kisseleva, David A Brenner
Feb 13, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Hideki IshidaKazunari Tanabe
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezM Valente
Nov 18, 2008·Transplantation Proceedings·J PéfaurL Contreras
Dec 24, 2008·Transplantation·Matthew J EverlyE Steve Woodle
Aug 18, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Banu SisPhilip F Halloran
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieMarshall I Hertz
Oct 22, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G EineckeP F Halloran
Mar 30, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P F Halloran
Sep 4, 2010·Journal of the American Society of Nephrology : JASN·Walter D ParkMark D Stegall
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B MannonUNKNOWN DeKAF Investigators
Dec 1, 2010·Kidney International. Supplement·Timothy M Millington, Joren C Madsen
Feb 8, 2011·Expert Opinion on Pharmacotherapy·Jessica G LucasKalathil K Sureshkumar
Mar 24, 2011·Journal of Hepatology·Stefan G Hübscher
Aug 20, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johannes WaiserNils Lachmann
Sep 29, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M D StegallJ M Gloor
Nov 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J SellarésP F Halloran
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M MengelUNKNOWN Banff meeting report writing committee
Mar 8, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas Fehr, Ariana Gaspert
Feb 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GreerT Fuehner
Apr 18, 2013·Current Opinion in Organ Transplantation·Jacqueline G O'Leary, Göran B Klintmalm
Jul 11, 2013·Current Opinion in Organ Transplantation·Duska DragunAurélie Philippe

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Citations

Aug 22, 2017·Transplantation·Yoshito YamadaWolfgang Jungraithmayr
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhaoyan KongYuanrong Cheng

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