Chronic rejection in lung allografts: immunohistological analysis of fibrogenesis

Transplant International : Official Journal of the European Society for Organ Transplantation
T HirabayashiB Nashan

Abstract

In ongoing chronic rejection after lung transplantation, alveolar interstitial fibrosis develops. However, little is known about the mechanisms involved. In order to investigate these mechanisms, expression of extracellular matrix molecules (ECM) (undulin, decorin, tenascin, laminin, and fibronectin) and cytokines [transforming growth factor (TGF)-beta 1, TGF-beta 3, platelet-derived growth factor (PDGF), and PDGF receptor] were semiquantitatively evaluated in chronically rejected lung allografts, using standard immunohistochemical techniques. Additionally, the presence of macrophages was analysed. The present study demonstrates an increased infiltration of macrophages with a concomitant upregulation of cytokines (TGF-beta 1, TGF-beta 3, and PDGF) and an increased deposition of ECM in chronic lung rejection. These cytokines have an important role in the stimulation of fibroblasts which are a major source of ECM. Upregulated expression of ECM in the alveolar interstitial space leads to alveolar malfunction by thickening of the wall and, thus, is one of the causative factors of respiratory dysfunction in chronic lung graft rejection.

References

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Citations

Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lucas LawTrevor J Williams
Dec 22, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M P RevellR S Bonser
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A El-GamelI V Hutchinson
Dec 22, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G M VerledenM Demedts
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Robert M ArisIsabel P Neuringer
Aug 19, 2008·Seminars in Thoracic and Cardiovascular Surgery·Masaaki Sato, Shaf Keshavjee
Mar 18, 1999·Transplant International : Official Journal of the European Society for Organ Transplantation·E A KouwenhovenN M Thomson
Sep 20, 2018·American Journal of Respiratory Cell and Molecular Biology·Fang-Fang DuanLucia Schuger
Jun 24, 1998·Scandinavian Cardiovascular Journal : SCJ·M BergmannA Haverich

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