Chronic Relapsing Experimental Allergic Encephalomyelitis in the SJL Mouse: Relevant Techniques

Methods : a Companion to Methods in Enzymology
Rhonda R Voskuhl

Abstract

Experimental allergic encephalomyelitis (EAE) is a useful animal model for the study of autoantigen-specific T-lymphocyte responses in autoimmune demyelinating diseases of the central nervous system. EAE models, however, are quite variable clinically, pathologically, and immunologically depending upon both host factors and the method of disease induction. Since EAE in the SJL mouse presents as a chronic relapsing disease characterized by primary demyelination, it is an ideal model for the study of autoimmune mediated demyelination and immunoregulatory events leading to relapses in the human disease multiple sclerosis. This report reviews host factors that influence EAE, then focuses upon EAE in the SJL mouse in a detailed description of methodologies involved in passive and active EAE induction. The advantages of each induction method, passive and active, are discussed.

Citations

Jan 13, 2000·Neuropathology and Applied Neurobiology·J E Merrill, N J Scolding
Dec 8, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michael ValerioAtif B Awad
Aug 14, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·R R Voskuhl, K Palaszynski
Nov 22, 2016·Journal of Neuroscience Research·Lisa C Golden, Rhonda Voskuhl

❮ Previous
Next ❯

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.