Chronic relapsing neuropathy associated with Castleman's disease (angiofollicular lymph node hyperplasia)

European Neurology
F VingerhoetsF Regli

Abstract

We report a 17-year-old patient who presented a chronic relapsing sensorimotor demyelinating neuropathy with 6 relapses over a 7-year period, preceding by 4 years the diagnosis of a multicentric angiofollicular lymph node hyperplasia. A role for Epstein-Barr virus (EBV) as a trigger of the neuropathy may be suggested by the presence of EBV DNA in the biopsied abdominal abdominal adenopathies. This unusual reported association seems to have a better prognosis than the known chronic progressive form of neuropathy associated with Castleman's disease and the Crow-Fukase syndrome.

Citations

Jul 13, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L Fernández-TorreJ Berciano
May 19, 2010·The Oncologist·Myrna R Rosenfeld, Josep Dalmau
Dec 5, 2000·Muscle & Nerve·S A Rudnicki, J Dalmau

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Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

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