PMID: 9423818Jan 10, 1998Paper

Chronic relapsing thrombotic thrombocytopenic purpura: role of therapy with cyclosporine

American Journal of Hematology
D PasqualeG Chikkappa

Abstract

Relapsing thrombotic thrombocytopenic purpura (TTP) is a rare disorder with most individuals experiencing 1 to 5 relapses. We report a patient with 18 episodes of thrombotic thrombocytopenic purpura (TTP), the highest number of relapses thus far described. The last 11 episodes were treated with regimens containing cyclosporine. The patient's medical record was reviewed for pertinent clinical, laboratory, and treatment data. We summarized various parameters for each episode and compared characteristics of relapses treated with vs. without cyclosporine. The initial episode of TTP was unusual in that it failed to respond to plasmapheresis, glucocorticoids, and fresh frozen plasma (FFP). It remitted only following splenectomy. Episodes 2-7 responded to FFP plus prednisone. Episode 8 failed to respond to prednisone plus FFP but remitted promptly with cyclosporine plus prednisone. Subsequently, 2 relapses responded to cyclosporine alone, 2 to cyclosporine plus FFP, 4 to cyclosporine plus prednisone +/- FFP, and 2 to cyclosporine, FFP, prednisone, and plasma exchange. There was no difference in remission duration, or in severity or duration of relapses treated with vs. without cyclosporine. Use of cyclosporine, however, significantly ...Continue Reading

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Citations

May 26, 2012·British Journal of Haematology·Marie ScullyUNKNOWN British Committee for Standards in Haematology
Jul 30, 2014·Transfusion·Jay S RavalYara A Park
Jan 24, 2006·Blood Reviews·R J A Murrin, J A Murray
Nov 6, 2002·International Journal of Hematology·Annamaria NosariEnrica Morra
Feb 27, 2003·Southern Medical Journal·Martin G V Perez, Francis R Rodwig
May 13, 2006·Journal of Thrombosis and Haemostasis : JTH·S R CatalandH M Wu
Jul 11, 2000·British Journal of Haematology·G A Rock
Aug 12, 2005·Current Opinion in Hematology·Spero R Cataland, Haifeng M Wu
Jun 23, 2009·Pediatric Blood & Cancer·Maria C BouwNicole L Ramakers-van Woerden
Mar 19, 2015·Blood·Farzana A Sayani, Charles S Abrams
Feb 26, 2020·Therapeutic Advances in Hematology·Ashley Hanlon, Ara Metjian
Feb 3, 1999·American Journal of Hematology·M Yeter, G Bagçecik
Feb 18, 2003·British Journal of Haematology·Sarah L AllfordUNKNOWN Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology
Feb 21, 2007·Expert Opinion on Pharmacotherapy·Spero R Cataland, Haifeng M Wu
Nov 9, 2021·Expert Review of Hematology·Katerina PavenskiChristopher J Patriquin

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