Chronic renal neuroadrenergic hypertension is associated with increased renal norepinephrine sensitivity and volume contraction

Hypertension
C F Plato, J L Osborn

Abstract

Individuals with essential hypertension have been characterized by increased renal sympathetic vascular tone with decreased plasma volume and normal cardiac output compared with normotensive individuals. We used a servo-controlled intrarenal infusion system to evaluate the hemodynamic, renal excretory, and plasma hormonal responses to 28-day, low-level elevations in the intrarenal adrenergic neurotransmitter norepinephrine. In uninephrectomized dogs (n = 6), servo-controlled norepinephrine infusion increased mean arterial pressure from 95.6 +/- 3.1 to 115.7 +/- 4.9 mm Hg on day 1 without concomitant reductions in renal blood flow. Arterial hypertension was sustained and renal vascular resistance increased during the 28 days of servo-controlled norepinephrine infusion despite significant decreases in the daily dose of intrarenal norepinephrine (1.49 +/- 0.23 to 0.47 +/- 0.25 mg/d) necessary to maintain renal blood flow constant. Arterial pressure returned to control values with the cessation of servo-controlled norepinephrine, whereas renal blood flow and renal vascular resistance remained slightly decreased and increased, respectively. Cumulative sodium balance exhibited a net 177 +/- 37 mmol sodium loss over the 28 days of nor...Continue Reading

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Citations

Dec 14, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E D BruderH Raff
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·J L OsbornX R He
Apr 27, 2004·Journal of Hypertension·Olaf GriskRainer Rettig
Dec 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gerald F DiBona, Murray Esler
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon C Malpas
Oct 6, 1997·The Medical Clinics of North America·L G Navar

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