Abstract
The use of angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) for the treatment of hypertensive obese patients is steadily increasing. Some studies have reported that the use of these drugs was associated with an increased risk of hypotensive episodes, during general anaesthesia. The number of bariatric procedures is also increasing worldwide, but there is a lack of studies investigating the hypotensive effect of renin-angiotensin system (RAS) blockers in severely obese patients during general anaesthesia for bariatric surgery. The aim of this pilot study was to evaluate hemodynamic changes induced by general anaesthesia in obese patients chronically treated with ACE-I or ARB compared to a control group not treated with antihypertensive therapy. Fourteen obese subjects (mean body mass index (BMI) 47.5 kg/m(2)) treated with ACE-I or ARB and twelve obese (mean BMI 45.7 kg/m2) controls not treated with antihypertensive therapy underwent general anaesthesia to perform laparoscopic bariatric surgery. Systolic blood pressure, diastolic blood pressure, and heart rate were monitored continuously and registered at different time points: T0 before induction, then at 2, 5, 7, 10, 15, 20, 30, 60, 90...Continue Reading
References
Aug 1, 1989·Journal of Cardiothoracic Anesthesia·J H KatajaH Vapaatalo
Jan 1, 1993·Anesthesia and Analgesia·K S Chang, R F Davis
Nov 30, 1999·Anesthesia and Analgesia·P ColsonP Coriat
Dec 10, 1999·Anesthesia and Analgesia·S M BrabantP Coriat
Aug 6, 2000·Obesity Surgery·A C Wittgrove, G W Clark
Jan 3, 2001·Anesthesia and Analgesia·M BertrandP Coriat
Sep 29, 2001·British Journal of Anaesthesia·A M MaguireJ P Thompson
Mar 28, 2002·Anesthesia and Analgesia·Karoline MeersschaertPierre Coriat
Feb 7, 2003·Current Pharmaceutical Design·Rahim BehniaRajko Igić
May 27, 2003·Anesthesiology·Gilles BoccaraPierre Coriat
Feb 25, 2005·Anesthesia and Analgesia·Thomas ComfereDavid O Warner
Apr 25, 2006·Critical Care : the Official Journal of the Critical Care Forum·Ali AraghiJorge A Guzman
Nov 4, 2006·Journal of Hypertension·Enrico Agabiti RoseiCsaba Farsang
Apr 1, 2008·Journal of Cardiothoracic and Vascular Anesthesia·John G T Augoustides
Apr 1, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Sachin KheterpalKevin K Tremper
Sep 30, 2009·Obesity Surgery·P K ChowbeyT Mittal
Mar 29, 2011·Postgraduate Medical Journal·Moises AuronFranklin Michota
May 11, 2012·Journal of Hypertension·Jens JordanNick Finer
Feb 16, 2013·Current Medicinal Chemistry·M Ramírez-SánchezM de Gasparo
Apr 1, 2014·Anesthesia and Analgesia·Rebecca S TwerskyJeremy Weedon
Dec 1, 2014·Critical Care : the Official Journal of the Critical Care Forum·Stefano RomagnoliA Raffaele De Gaudio
Citations
Feb 28, 2018·BMC Anesthesiology·Qiong LingQianqian Zhu
Jul 8, 2020·Anesthesia Progress·Takayuki HojoToshiaki Fujisawa
Jul 15, 2017·Current Obesity Reports·Asta LukosiuteJonathan Mark Cousins
Feb 8, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Uzung YoonTara Kennedy
Sep 18, 2021·Anaesthesia Critical Care & Pain Medicine·Victoria A EleyAndré A van Zundert
Jun 20, 2017·Journal of Clinical Anesthesia·Luis Mario Vaquero RonceroJosé María Calvo Vecino