Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus

Brain Research
Tatiana F Ejchel-CohenL Trevor Young

Abstract

Chronic restraint stress in mice affects hippocampal structure and function. Mice were subjected to daily restraint for 3 weeks, and gene expression in hippocampus was compared to controls using large-scale cDNA microarrays. We found that 444 genes were differentially expressed, and further analysis of 6 genes by real-time reverse transcription PCR confirmed that 3 of them were downregulated by stress. These 3 genes, growth factor receptor-bound protein 2 (Grb2), phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (Pip5k1b), and glutathione S-transferase, pi2 (Gstp2), were also analyzed by in situ hybridization. The downregulation of Gstp2 may induce an increase of oxidative damage in the pyramidal cells of the CA1 and CA3 regions and granular layer of the dentate gyrus, leading to structural and functional damage. Those regions are affected by stress, and our results could help understand further the mechanisms involved in the occurrence of stress-related disorders.

References

Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Jan 1, 1992·Neurobiology of Aging·R M Sapolsky
Jun 21, 1997·Annals of the New York Academy of Sciences·B S McEwen, A M Magarinos
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Oct 6, 1999·Current Opinion in Neurobiology·S S GrewalP J Stork
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A AlessandriniJ V Bonventre
Nov 7, 2000·Biological Psychiatry·B S McEwen
Nov 20, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bruce S McEwen, Sumantra Chattarji
May 7, 2005·Metabolism: Clinical and Experimental·Bruce S McEwen

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Citations

Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard G HunterBruce S McEwen
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
May 23, 2013·PloS One·Christian Ansgar HundahlGregers Wegener
Sep 18, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Hua-Yu LianJing-He Tan
Dec 18, 2013·Molecular Psychiatry·J D GrayB S McEwen
Jul 7, 2007·Stress : the International Journal on the Biology of Stress·Sâmia Regiane Lourenço JocaFrancisco Silveira Guimarães
Feb 6, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H Le-NiculescuA B Niculescu
Mar 6, 2010·Annals of the New York Academy of Sciences·Bruce S McEwen, Peter J Gianaros
Oct 22, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pawel LisowskiArtur H Swiergiel
Feb 22, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jane H ChristensenAnders D Børglum
Oct 14, 2008·Stress : the International Journal on the Biology of Stress·Ayesha Zafir, Naheed Banu
Nov 9, 2017·International Journal of Molecular Medicine·Hwayoung LeeHak-Jae Kim
Jul 15, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hwayoung LeeHak-Jae Kim
May 6, 2017·European Archives of Psychiatry and Clinical Neuroscience·Ivana PerićDragana Filipović

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