Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

Journal of Neurochemistry
Jaesuk YunKiyofumi Yamada

Abstract

Neurogenesis in the hippocampus occurs throughout life in a wide range of species and could be associated with hippocampus-dependent learning and memory. Stress is well established to seriously perturb physiological/psychological homeostasis and affect hippocampal function. In the present study, to investigate the effect of chronic restraint stress in early life on hippocampal neurogenesis and hippocampus-dependent memory, 3-week-old mice were subjected to restraint stress 6 days a week for 4 weeks. The chronic restraint stress significantly decreased the hippocampal volume by 6.3% and impaired hippocampal neurogenesis as indicated by the reduced number of Ki67-, 5-bromo-2'-deoxyuridine- and doublecortin-positive cells in the dentate gyrus. The chronic restraint stress severely impaired hippocampus-dependent contextual fear memory without affecting hippocampus-independent fear memory. The expression level of brain-specific transcription factor neuronal PAS domain protein 4 (Npas4) mRNA in the hippocampus was down-regulated by the restraint stress or by acute corticosterone treatment. Npas4 immunoreactivity was detected in progenitors, immature and mature neurons of the dentate gyrus in control and stressed mice. Our findings su...Continue Reading

References

Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N BraunH K Müller-Hermelink
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·V LemaireD N Abrous
Jun 4, 2002·Nature Reviews. Neuroscience·Jeansok J Kim, David M Diamond
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Taku NagaiToshitaka Nabeshima
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·John F ReillyFloyd E Bloom
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Jan 31, 2004·The European Journal of Neuroscience·Vivi M HeinePaul J Lucassen
Jul 27, 2004·Nature Neuroscience·Christian MirescuElizabeth Gould
Nov 25, 2004·Brain Research Bulletin·Christel WestenbroekGert J Ter Horst
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikko SairanenEero Castrén
Jun 15, 2005·Neurobiology of Aging·M F MontaronD N Abrous
Jan 18, 2006·Hippocampus·Christian Mirescu, Elizabeth Gould
Jan 20, 2006·Hippocampus·Benedetta LeunerTracey J Shors
Mar 8, 2006·Experimental & Molecular Medicine·Kuem-Ju LeeKyung-Ho Shin
Jul 15, 2006·Behavioural Brain Research·Jasmine J YapBarry L Jacobs
Dec 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christian MirescuElizabeth Gould
Jun 20, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kazufumi NagataShigeo Ohta
Jul 16, 2008·Nature Neuroscience·Nicolas ToniAlejandro F Schinder
Aug 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eri Segi-NishidaRonald S Duman
Sep 2, 2008·Nature Neuroscience·Itaru ImayoshiRyoichiro Kageyama
Sep 26, 2008·Nature·Yingxi LinMichael E Greenberg
Dec 3, 2008·The European Journal of Neuroscience·Y W J LiuR L M Faull
Sep 15, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P J LucassenB Czéh

❮ Previous
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Citations

Sep 29, 2011·Psychopharmacology·Kamilla W MiskowiakLars V Kessing
May 30, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jay S SchneiderRajanikanth Vadigepalli
Nov 7, 2012·BMC Neuroscience·Asim K BepariHirohide Takebayashi
Feb 2, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiromi HayashiYoshihisa Kitamura
Jul 19, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhaohui ZhangJinggui Song
Jun 3, 2014·Stem Cell Research & Therapy·Thomas S KlaricMartin D Lewis
Jan 23, 2016·Frontiers in Integrative Neuroscience·Jiah Pearson-LearyEwan C McNay
Sep 30, 2014·Neuroscience and Biobehavioral Reviews·Syed Mohammed Qasim HussainiMi-Hyeon Jang
Jan 29, 2016·Proceedings. Biological Sciences·C DePasqualeV A Braithwaite
Jan 27, 2016·Molecular Psychiatry·M F Rubin de CelisM Ehrhart-Bornstein
Dec 24, 2011·Behavioural Brain Research·Lieve DesbonnetColm M P O'Tuathaigh
Dec 4, 2015·Frontiers in Neuroanatomy·Joanne C DamborskyUrsula H Winzer-Serhan
Mar 19, 2016·Trends in Neurosciences·Xiaochen Sun, Yingxi Lin
Feb 12, 2011·Journal of Neuroscience Research·Yasuhito WakasayaMikio Shoji
Apr 26, 2015·Behavioural Brain Research·Laurence CoutellierRyan Shepard
May 23, 2015·Frontiers in Neuroscience·Danielle M OsborneEwan C McNay
Apr 19, 2015·Trends in Neurosciences·Scott M ThompsonXiang Cai
Feb 22, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jane H ChristensenAnders D Børglum
Feb 18, 2015·Behavioural Brain Research·Yuki OtaToshio Matsuda
Nov 1, 2011·Neuroscience and Biobehavioral Reviews·Thibault RenoirLaurence Lanfumey
Aug 17, 2011·Neuropharmacology·Adam StewartAllan V Kalueff
Feb 24, 2015·Frontiers in Psychiatry·Susana MonteiroJoão José Cerqueira
Oct 17, 2012·The International Journal of Neuropsychopharmacology·Karem H AlzoubiKarim A Alkadhi
Mar 2, 2011·The International Journal of Neuropsychopharmacology·Karim A AlkadhiTrinh T Tran
Nov 5, 2016·Neuroscience·Catherine LauJacqueline Blundell

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