Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Suzie Hyeona KangRaphaella de Oliveira Migliavacca

Abstract

Although cystic fibrosis (CF) is an irreversible genetic disease, advances in treatment have increased the life expectancy of CF patients. Upper airway involvement, which is mainly due to pathological changes in the paranasal sinuses, is prevalent in CF patients, although many are only mildly symptomatic (with few symptoms). The objective of this literature review was to discuss the pathophysiology and current therapeutic management of chronic rhinosinusitis (CRS) in CF patients. The review was based on current evidence, which was classified in accordance with the Oxford Centre for Evidence-Based Medicine criteria. When symptomatic, CRS with nasal polyps can affect quality of life and can lead to pulmonary exacerbations, given that the paranasal sinuses can be colonized with pathogenic bacteria, especially Pseudomonas aeruginosa. Infection with P. aeruginosa plays a crucial role in morbidity and mortality after lung transplantation in CF patients. Although clinical treatment of the upper airways is recommended as initial management, this recommendation is often extrapolated from studies of CRS in the general population. When sinonasal disease is refractory to noninvasive therapy, surgery is indicated. Further studies are needed...Continue Reading

Citations

Nov 28, 2016·Otolaryngologic Clinics of North America·Corinna G Levine, Roy R Casiano
Mar 9, 2018·Current Opinion in Pulmonary Medicine·Fernando A L Marson
Nov 28, 2017·Molecular Genetics & Genomic Medicine·Sofía C OrtizLilian Salinas
Jan 13, 2018·International Forum of Allergy & Rhinology·Gopi B ShahAshleigh Halderman
Nov 26, 2018·International Forum of Allergy & Rhinology·Justin McCormickBradford A Woodworth
Oct 18, 2016·F1000Research·Alexandria F JakshaAdrienne M Laury
Oct 24, 2019·The Cochrane Database of Systematic Reviews·Tulasi Kota KaranthLaxminarayan Karanth
Jun 24, 2017·AJR. American Journal of Roentgenology·Sarah AverillPerry J Pickhardt
Jan 26, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Angelica TiotiuFulvio Braido
Sep 4, 2018·International Journal of Pediatric Otorhinolaryngology·Michelle ManziniPaulo José CauduroMarostica
Jun 14, 2019·International Journal of Pediatric Otorhinolaryngology·Anne S LoweryFrank W Virgin
May 27, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Claudia GrehnUNKNOWN Registry working group of the German CF Registry
Jul 24, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Joanna KrajewskaTomasz Zatoński

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Methods Mentioned

BETA
bronchoalveolar lavage
lavage
nuclear magnetic resonance

Software Mentioned

FESS

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