Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats

Biogerontology
Po Yee ChiuKam-Ming Ko

Abstract

The effects of chronic schisandrin B (Sch B) treatment (10 mg/kg/dayx15) on mitochondrial antioxidant status and sensitivity to Ca2+-induced permeability transition, as well as tissue heat shock protein (Hsp)25/70 production were examined in various tissues (brain, heart, liver, skeletal muscle) of young adult and middle-aged female rats. Age-dependent impairment in mitochondrial antioxidant status, as assessed by levels/activities of antioxidant components (reduced glutathione, alpha-tocopherol, Se-glutathione peroxidase and Mn-superoxide dismutase) and the extent of reactive oxygen species generation in vitro, was observed in brain, heart, liver and skeletal muscle tissues. While tissue Hsp25 levels remained relatively unchanged with aging, the Hsp70 level was increased in both brain and heart tissues of middle-aged rats. Chronic Sch B treatment was able to enhance mitochondrial antioxidant status and the resistance to Ca2+-induced mitochondrial permeability transition in an age-independent manner in various tissues of rats. However, Hsp25 and Hsp70 levels were only increased in young adult rats. The Sch B-induced enhancement of mitochondrial protective parameters in the heart was associated with the protection against myocar...Continue Reading

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Citations

Oct 19, 2006·Biogerontology·Anis LarbiGraham Pawelec
Mar 4, 2011·Biological Trace Element Research·Wei LiuYangang Wei
Sep 8, 2011·Clinical and Experimental Pharmacology & Physiology·Pou K LeongKam M Ko
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Sep 11, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tae Hwa LeeDae-Hee Lee
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Mar 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Pou Kuan LeongKam Ming Ko
Mar 1, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Qiu-Ning LinXiao Qin

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