Chronic smoking and alcoholism change expression of selective genes in the human prefrontal cortex.

Alcoholism, Clinical and Experimental Research
Traute Flatscher-Bader, Peter A Wilce

Abstract

Alcoholism is commonly associated with chronic smoking. A number of gene expression profiles of regions within the human mesocorticolimbic system have identified potential alcohol-sensitive genes; however, the influence of smoking on these changes was not taken into account. This study addressed the impact of alcohol and smoking on the expression of 4 genes, previously identified as alcoholism-sensitive, in the human prefrontal cortex (PFC). mRNA expression of apolipoprotein D, tissue inhibitor of the metalloproteinase 3, high-affinity glial glutamate transporter and midkine, was measured in the PFC of alcoholic subjects and controls with and without smoking comorbidity using real-time polymerase chain reaction. The results show that alcohol affects transcription of some of these genes. Additionally, smoking has a marked influence on gene expression. This study emphasizes the need for careful case selection in future gene expression studies to delineate the adaptive molecular process associated with smoking and alcohol.

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Nov 11, 2009·Nutrition Research Reviews·Traute Flatscher-Bader, Peter A Wilce
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Jul 29, 2008·Alcoholism, Clinical and Experimental Research·Traute Flatscher-Bader, Peter A Wilce
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May 19, 2010·Alcoholism, Clinical and Experimental Research·Traute Flatscher-BaderPeter A Wilce
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Jan 23, 2020·Cold Spring Harbor Perspectives in Medicine·Mirit LiranSegev Barak
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