Chronic social defeat stress disrupts regulation of lipid synthesis.

Journal of Lipid Research
Jen-Chieh ChuangMichael Lutter

Abstract

Several psychiatric disorders increase the risk of cardiovascular disease, including posttraumatic stress disorder and major depression. While the precise mechanism for this association has not yet been established, it has been shown that certain disorders promote an unfavorable lipid profile. To study the interaction of stress and lipid dysregulation, we utilized chronic social defeat stress (CSDS), a mouse model of chronic stress with features of posttraumatic stress disorder and major depression. Following exposure to CSDS, mice were given access to either regular chow or a Western-style diet high in fat and cholesterol (HFD). The combination of social stress and HFD resulted in significant perturbations in lipid regulation, including two key features of the metabolic syndrome: increased plasma levels of non-HDL cholesterol and intrahepatic accumulation of triglycerides. These effects were accompanied by a number of changes in the expression of hepatic genes involved in lipid regulation. Transcriptional activity of LXR, SREBP1c, and ChREBP were significantly affected by exposure to HFD and CSDS. We present CSDS as a model of social stress induced lipid dysregulation and propose that social stress alters lipid metabolism by i...Continue Reading

References

Jun 1, 1982·Archives of General Psychiatry·W CoryellJ Clancy
Sep 1, 1994·Archives of General Psychiatry·C Allgulander
Jan 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y DeshaiesL J Bukowiecki
Dec 16, 1998·The British Journal of Psychiatry : the Journal of Mental Science·E C Harris, B Barraclough
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·A SgoifoP Meerlo
Jan 31, 2002·Annual Review of Medicine·Roger H Unger
May 8, 2002·The Journal of Clinical Investigation·Jay D HortonMichael S Brown
Apr 12, 2003·Molecular Endocrinology·Peter Tontonoz, David J Mangelsdorf
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Loubna Erraji-BenchekrounClaudine André
Oct 5, 2006·The Journal of Clinical Psychiatry·Tuula H HeiskanenHeimo T Viinamäki
Aug 8, 2007·Cell Metabolism·Liora CaspiTony K T Lam
Jan 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M Grundy
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael LutterEric J Nestler
May 3, 2008·The Journal of Clinical Investigation·Jean-Eric GhiaStephen M Collins
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Jun 17, 2008·Nature Neuroscience·Michael LutterJeffrey M Zigman
Aug 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria Frank-KamenetskyKevin Fitzgerald
Sep 4, 2008·The American Journal of Psychiatry·Vaishnav KrishnanEric Nestler
Feb 20, 2009·The Journal of Biological Chemistry·Markey C McNuttThomas A Lagace
Apr 7, 2009·Journal of Psychopharmacology·S J C DaviesD J Nutt
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisa FabbriniSamuel Klein

❮ Previous
Next ❯

Citations

Jul 30, 2011·Nature Protocols·Sam A GoldenScott J Russo
Jun 28, 2011·The Journal of Clinical Investigation·Jen-Chieh ChuangJeffrey M Zigman
Jun 2, 2011·Drug Metabolism and Pharmacokinetics·Yasuhiro YamazakiJunko Sugatani
Jul 14, 2012·Molecular and Cellular Endocrinology·Romana StarkZane B Andrews
Mar 31, 2012·Biological Psychiatry·Mario Perelló, Jeffrey M Zigman
Mar 11, 2015·Molecular Psychiatry·T G OliveiraN Sousa
Aug 1, 2015·Journal of Nutritional Science and Vitaminology·Atsushi ToyodaTakamitsu Tsukahara
Oct 2, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·André Miguel Miranda, Tiago Gil Oliveira
Dec 17, 2014·Neurobiology of Stress·Madeline L Pfau, Scott J Russo
Mar 4, 2014·Stress : the International Journal on the Biology of Stress·Daniela OrtolaniRegina Celia Spadari-Bratfisch
Dec 30, 2014·Biochimica Et Biophysica Acta·Christian P MüllerJohannes Kornhuber
Dec 3, 2014·Psychoneuroendocrinology·En-Ju D LinMatthew J During
Feb 24, 2015·Brain, Behavior, and Immunity·Xudong FengLi-Na Wei
Jan 13, 2015·Neuroscience and Biobehavioral Reviews·Rodrigo B MansurRoger S McIntyre
Dec 7, 2010·Behavioural Brain Research·Maria RazzoliDavid M Sokal
Sep 25, 2010·Pharmacology, Biochemistry, and Behavior·Maria RazzoliRoberto Arban
Dec 2, 2014·Journal of Proteome Research·Tatsuhiko GotoAtsushi Toyoda
Mar 24, 2017·Journal of Proteome Research·Tatsuhiko GotoAtsushi Toyoda
Jul 22, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Wataru IioAtsushi Toyoda
Mar 19, 2019·PloS One·Synthia H MellonOwen M Wolkowitz
Apr 19, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Saeid GolbidiIsmail Laher
Aug 30, 2017·Frontiers in Molecular Neuroscience·Mylène HervéEl Chérif Ibrahim
Aug 25, 2018·Translational Psychiatry·Moriah L JacobsonDavid McKinnon
Dec 14, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio V AubryNesha S Burghardt
Feb 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiuxia PanJiaxu Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.