Chronic Social Stress Affects Synaptic Maturation of Newly Generated Neurons in the Adult Mouse Dentate Gyrus

The International Journal of Neuropsychopharmacology
Chien-Chung ChenKuei-Sen Hsu

Abstract

Chronic stress has been found to suppress adult neurogenesis, but it remains unclear whether it may affect the maturation process of adult-born neurons. Here, we examined the influence of chronic social defeat stress on the morphological and electrophysiological properties of adult-born dentate granule cells at different developmental stages. Adult C57BL/6 mice were subjected to 10 days of chronic social defeat stress followed by a social interaction test 24 hours after the last defeat. Defeated mice were segregated into susceptible and unsusceptible subpopulations based on a measure of social interaction test. Combining electrophysiology with retrovirus-mediated birth-dating and labeling, we examined the impact of chronic social defeat stress on temporal regulation of synaptic plasticity of adult-born dentate granule cells along their maturation. Chronic social defeat stress decreases the survival and dendritic complexity of adult-born dentate granule cells. While chronic social defeat stress doesn't alter the intrinsic electrophysiological properties and synaptic transmission of surviving adult-born dentate granule cells, it promotes the developmental switch in synaptic N-methyl-D-aspartate receptors from predominant GluN2B- ...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Jun 2, 2001·Journal of Neurophysiology·J S SnyderJ M Wojtowicz
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R S DumanJ Malberg
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Sep 3, 2004·Neuroscience Letters·Megan J BainBenjamin Rusak
Oct 21, 2004·Science's STKE : Signal Transduction Knowledge Environment·Stuart G Cull-Candy, Daniel N Leszkiewicz
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Soledad EspósitoAlejandro F Schinder
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
Mar 8, 2006·Experimental & Molecular Medicine·Kuem-Ju LeeKyung-Ho Shin
Nov 24, 2006·PLoS Biology·Diego A LaplagneAlejandro F Schinder
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boldizsár CzéhEberhard Fuchs
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing-Wen WangRené Hen
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Diane C LagaceAmelia J Eisch
May 27, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Verónica C PiattiAlejandro F Schinder
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhengliang GaoJenny Hsieh
Apr 11, 2012·Developmental Neurobiology·Matteo Bergami, Benedikt Berninger
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mazen A KheirbekRené Hen
Sep 11, 2012·Nature Neuroscience·Alma Rodenas-RuanoR Suzanne Zukin
Nov 29, 2012·Nature Neuroscience·Timothy J Schoenfeld, Elizabeth Gould
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael L LehmannMiles Herkenham
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica H ChanceyLinda S Overstreet-Wadiche
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christoph AnackerCarmine M Pariante

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Citations

Jun 1, 2018·Integrative Zoology·Claudia Jorgensen
Sep 29, 2017·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Laura B ZahodneZarina Kraal
Nov 28, 2018·Innovation in Aging·Kristine J AjrouchToni C Antonucci
Aug 13, 2020·Biomolecules·Claudia Jorgensen, Zuoxin Wang
Jul 7, 2019·Brain Sciences·Claudia JorgensenTyler Barton
Aug 3, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomoko SogaIshwar S Parhar

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