Chronic social stress increases levels of preprogalanin mRNA in the rat locus coeruleus

Pharmacology, Biochemistry, and Behavior
P V HolmesJacqueline N Crawley

Abstract

Galanin is a 29 amino acid neuropeptide that coexists with norepinephrine in approximately 80% of locus coeruleus (LC) neurons in the rat. The effects of chronic, naturalistic stress on preprogalanin mRNA in the LC was studied. The visible burrow system (VBS) served as the stress paradigm. Long-Evans rats (three males and two females) were housed together in the VBS for 13 days. The males established dominance hierarchies during this period. On day 14, preprogalanin mRNA in the LC was significantly elevated in subordinate rats compared to dominant and control rats, as measured by quantitative in situ hybridization. Levels of mRNA were positively correlated with the number of wounds by day 7 and day 14 and negatively correlated with body weight gain by day 14. These results suggest that the neuropeptide galanin may be overexpressed during chronic stress in rats.

References

Aug 1, 1979·European Journal of Pharmacology·J N CrawleyR H Roth
Sep 1, 1992·Brain Research. Molecular Brain Research·K Kadowaki, P C Emson
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·D C Blanchard, R J Blanchard
Jun 22, 1986·The Journal of Comparative Neurology·T MelanderA Rökaeus
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A Rökaeus, M J Brownstein
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·G B Glavin
Mar 1, 1989·Journal of Comparative Psychology·R J Blanchard, D C Blanchard
Jan 1, 1986·Progress in Neurobiology·B L Jacobs
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 15, 1995·Biological Psychiatry·C R McKittrickR R Sakai
Jan 1, 1993·Brain Research Bulletin·A L CurtisR J Valentino
Jan 1, 1964·Acta Physiologica Scandinavica. Supplementum·C J CLEMEDSON, A JOENSSON

❮ Previous
Next ❯

Citations

Feb 19, 2005·Psychopharmacology·Valeriy SergeyevTomas Hökfelt
Dec 22, 2007·Neuroscience and Behavioral Physiology·V I LyudynoV M Klimenko
Feb 1, 1996·Brain Research. Molecular Brain Research·P V Holmes, J N Crawley
Feb 27, 2004·Physiology & Behavior·Kellie L K TamashiroRandall R Sakai
Nov 20, 2002·Biological Psychiatry·Justine M KentJack M Gorman
Jul 5, 2001·Physiology & Behavior·R J BlanchardD C Blanchard
Dec 24, 1997·Brain Research. Molecular Brain Research·J Y TsengM A Miller
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Mar 20, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul G UnschuldElisabeth B Binder
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kimberly A PearsonRita J Valentino
Jan 4, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugenia KuteevaSven Ove Ogren
Feb 3, 1999·Annals of the New York Academy of Sciences·M A Miller
Aug 30, 2013·BioMed Research International·Gianluca SerafiniPaolo Girardi
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Erwan Le MaîtreTomas G M Hökfelt
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gabriella JuhaszGyorgy Bagdy
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venetia ZachariouMarina R Picciotto
Jan 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takashi YoshitakeJan Kehr
May 26, 2009·Brain Research Bulletin·Nathaniel J ThomRod K Dishman
Nov 27, 2015·Brain Research·David Weinshenker, Philip V Holmes
Jul 10, 2012·Neuroscience and Biobehavioral Reviews·Natale R Sciolino, Philip V Holmes
Apr 21, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eugenia KuteevaSven Ove Ogren
Jul 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peng WangZhi-Qing David Xu
Aug 31, 2011·Behavioural Brain Research·Michail PavlidisPertti Panula
Apr 7, 2005·Behavioral and Cognitive Neuroscience Reviews·John K Robinson
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew HolmesJacqueline N Crawley
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kellie L K TamashiroRandall R Sakai
May 27, 2009·Nature Reviews. Neuroscience·Yvonne M Ulrich-Lai, James P Herman
Dec 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Swapnali BardeTomas G M Hökfelt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.