PMID: 8983876Oct 1, 1996Paper

Chronic sodium-potassium-ATPase inhibition with ouabain impairs renal haemodynamics and pressure natriuresis in the rat

Clinical Science
T KurashinaA Patel

Abstract

1. Chronic Na+, K(+)-ATPase inhibition with ouabain induces hypertension in the rat. To examine the role of the kidney in this process, the effect of changes in renal perfusion pressure on glomerular filtration rate, renal blood flow and urinary sodium excretion were determined in rats treated intraperitoneally with ouabain (27.8 micrograms day-1 kg-1 body weight) or vehicle for 6 weeks. 2. After ouabain administration, baseline mean arterial pressure was significantly higher (P < 0.05) in ouabain-treated rats (151 +/- 2 mmHg; n = 9) than in control rats (116 +/- 4 mmHg; n = 8). 3. At equivalent renal perfusion pressures, glomerular filtration rate was significantly lower (P < 0.05) in ouabain-treated rats compared with control rats. Glomerular filtration rate was 721 +/- 73 microliters/min at 150 mmHg, and fell significantly to 322 +/- 64 microliters/min at 100 mmHg. In the control group, glomerular filtration rate was well autoregulated. The glomerular filtration rate autoregulatory index was calculated to determine the ability to maintain glomerular filtration rate during changes in renal perfusion pressure (0 reflects perfect autoregulation; > 1 reflects the absence of autoregulation). This index was greater in the ouabain ...Continue Reading

Citations

Dec 19, 2014·Frontiers in Endocrinology·John M Hamlyn
Nov 30, 2006·American Journal of Physiology. Renal Physiology·Nancy J Hong, Jeffrey L Garvin
Oct 24, 2008·American Journal of Physiology. Renal Physiology·Chunhua CaoThomas L Pallone
Dec 1, 2012·American Journal of Physiology. Cell Physiology·Alessandra ZulianVera A Golovina
Dec 5, 2012·Current Opinion in Nephrology and Hypertension·John M Hamlyn, Mordecai P Blaustein
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raphael C ValenteMárcia A M Capella
Apr 8, 1998·Current Opinion in Nephrology and Hypertension·A Goto, K Yamada
Jul 3, 1999·Physiological Reviews·M P Blaustein, W J Lederer
Dec 11, 2017·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shabnam MohammadiAlan H Savitzky

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