Abstract
Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demographic data, clinical manifestations, disease activity/damage, laboratory abnormalities and treatment. A retrospective multicenter cohort study (Brazilian cSLE group) was performed in 10 Pediatric Rheumatology services and included 852 cSLE patients. CSU was diagnosed according to the guidelines of the European Academy of Allergy and Clinical Immunology, the Global Allergy and Asthma European Network, the European Dermatology Forum and the World Allergy Organization. Patients with CSU (evaluated at urticaria diagnosis) and patients without CSU (evaluated at the last visit) were assessed for lupus clinical/laboratory features and treatment. CSU was observed in 10/852 cSLE patients (1.17%). The median of cSLE duration at urticaria diagnosis was 0 (-3 to 5) years. Comparison of cSLE patients with and without CSU revealed a greater frequency of constitutional symptoms (40 vs. 8%, p = 0.006), reticuloendothelial system involvement (...Continue Reading
Citations
Nov 8, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Pavel KolkhirMarcus Maurer
Apr 11, 2017·Lupus·C C M ValõesUNKNOWN Brazilian Childhood-onset Systemic Lupus Erythematosus Group
Jan 31, 2017·Lupus·S R M LopesUNKNOWN Brazilian Childhood-onset Systemic Lupus Erythematosus Group
Jul 29, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chien-Hung LinKuan-Yu Hung
Aug 5, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Asya V KudryavtsevaPetra Staubach
Dec 21, 2019·Paediatric Drugs·Paul V Williams
Jun 25, 2016·Current Opinion in Rheumatology·Julie Couture, Earl D Silverman
Apr 18, 2018·International Journal of Dermatology·Hsien-Yi ChiuFung-Chang Sung
Nov 7, 2019·Frontiers in Immunology·Giuseppe A RamirezNorma Maugeri
May 26, 2017·PloS One·Ruru GuoJunjia Cao
Aug 11, 2018·Clinical Rheumatology·Juliana C O A FerreiraClovis Artur Silva
Jan 28, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Idit Lachover-RothRonit Confino-Cohen
Feb 25, 2019·Journal of the American Academy of Dermatology·Yossi RosmanRonit Confino-Cohen
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva