Chronic statin therapy and the risk of colorectal cancer

Pharmacoepidemiology and Drug Safety
Yu-Xiao YangJames D Lewis

Abstract

Epidemiologic studies on a potential chemopreventive effect of statin therapy have yielded conflicting results. We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort. A nested case-control study was conducted among patients > or =50 years of age and with > or =5 years of CRC-free initial follow-up in the General Practice Research Database (GPRD; 1987-2002). Cases consisted of all patients with incident CRC. Up to 10 controls were matched with each case on practice site and both duration and calendar time of follow-up prior to the index date. The primary exposure of interest was > or =5 years of cumulative statin use. We identified 4432 incident CRC cases and 44 292 controls. The adjusted odds ratio (OR) for > or =5 years of statin exposure was 1.1 (95% confidence interval (CI): 0.5-2.2). Chronic NSAID/aspirin use did not modify this primary association (test for interaction, p = 0.5). Compared to statin non-users, the adjusted OR for 10 years of statin exposure was 1.3 (95% CI: 0.6-2.7), and the adjusted OR associated with the highest quartile of cumulative statin dose was 1.2 (95% CI: 0.9-1.7). There was a non-stati...Continue Reading

References

Sep 11, 1992·Gastroenterology·S SumiJ C Thompson
Feb 1, 1990·Nature·J L Goldstein, M S Brown
Aug 15, 1986·International Journal of Cancer. Journal International Du Cancer·T J Eide
Apr 1, 1995·BMJ : British Medical Journal·J WeilP Wainwright
Jan 1, 1993·Annals of Internal Medicine·R L Koretz
May 25, 1993·Biochimica Et Biophysica Acta·C M Newman, A I Magee
Apr 6, 1999·The American Journal of Cardiology·J MölgaardA G Olsson
Apr 20, 2001·JAMA : the Journal of the American Medical Association·T P van StaaC Cooper
Feb 5, 2004·British Journal of Cancer·J A Kaye, H Jick
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthijs R GraafHenk-Jan Guchelaar
Oct 14, 2004·Gastroenterology·Yu-Xiao YangJames D Lewis
Dec 4, 2004·International Journal of Cancer. Journal International Du Cancer·Søren FriisJørgen H Olsen
May 27, 2005·The New England Journal of Medicine·Jenny N PoynterGad Rennert
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Krista M DaleC Michael White
Jan 5, 2006·Journal of the National Cancer Institute·Eric J JacobsEugenia E Calle
May 18, 2006·Journal of the National Cancer Institute·Jane A CauleyUNKNOWN Women's Health Initiative Research Group
Dec 21, 2006·Circulation·Soko SetoguchiSebastian Schneeweiss
Jan 5, 2007·Journal of the National Cancer Institute·Patricia F CooganLynn Rosenberg
Jan 20, 2007·Epidemiology·Patricia F CooganBrian L Strom
May 10, 2007·International Journal of Cancer. Journal International Du Cancer·Michael HoffmeisterHermann Brenner
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefanos BonovasNikolaos M Sitaras

❮ Previous
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Citations

Jul 7, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·G Karadeniz CakmakM Comert
Aug 19, 2011·Journal of the National Cancer Institute·Kimmie NgCharles S Fuchs
Dec 17, 2009·Journal of Gastroenterology and Hepatology·Yuk Kei YeeBenjamin C Y Wong
Jan 7, 2011·Cancer Prevention Research·Paul J LimburgUNKNOWN Cancer Prevention Network
Sep 29, 2011·BMC Cancer·Yana VinogradovaJulia Hippisley-Cox
Nov 23, 2013·Cancer Causes & Control : CCC·Yanqiong LiuXue Qin
Apr 10, 2010·Expert Opinion on Drug Safety·Denise M BoudreauJeanene Johnson
Dec 4, 2012·Expert Opinion on Drug Safety·Henry W C LeungHsiao-Ling Chen
Sep 18, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul Lochhead, Andrew T Chan
Mar 29, 2011·Vascular Pharmacology·Michael BergmanHanna Bessler
Sep 8, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Douglas J RobertsonHenrik Toft Sørensen
Dec 15, 2015·Pharmacoepidemiology and Drug Safety·Lucía Cea SorianoLuis A García Rodríguez
Dec 17, 2008·Pharmacoepidemiology and Drug Safety
Mar 3, 2012·Pharmacoepidemiology and Drug Safety·Rachel CharltonCorinne de Vries
Nov 18, 2015·BMC Cancer·Úna C Mc MenaminLiam M Murray
Aug 10, 2013·Trends in Pharmacological Sciences·Subash C GuptaBharat B Aggarwal
Mar 15, 2015·Journal of the National Cancer Institute·Michael HoffmeisterHermann Brenner
Aug 6, 2016·BMC Cancer·Úna C Mc MenaminChris R Cardwell
Nov 1, 2016·Current Atherosclerosis Reports·Ange WangMarcia L Stefanick
Apr 28, 2017·Clinical and Translational Gastroenterology·Ronan T GrayLiam J Murray
Apr 4, 2017·Journal of Thrombosis and Haemostasis : JTH·L Cea SorianoL A García Rodríguez
Oct 8, 2009·The American Journal of Gastroenterology·Harminder SinghCharles N Bernstein
Jul 7, 2017·British Journal of Cancer·Omolara B SanniHelen G Coleman
Jul 12, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Cornelia SchneiderChristoph R Meier
Oct 2, 2013·Nature Reviews. Clinical Oncology·Naomi Gronich, Gad Rennert
Oct 10, 2013·Diseases of the Colon and Rectum·Adam G MaceMatthew F Kalady
Mar 11, 2020·Seminars in Cancer Biology·Vijay P KaleManoj K Pandey

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