Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system

Molecular Psychiatry
T SherrinJ Spiess

Abstract

Corticotropin-releasing factor (CRF) and cholecystokinin (CCK), two highly colocalized neuropeptides, have been linked to the etiology of stress-related anxiety disorders. Recent evidence points to the possibility that some of the anxiogenic effects of the central CCK system take place through interplay with the CRF system. The aim of the present study was to examine the effects of chronic, mild activation of CRF receptor 1 (CRF(1)) on the central CCK system of the C57BL/6J mouse. As shown by in situ hybridization, real-Time PCR and immunohistochemistry, 5 days of intracerebroventricular (i.c.v.) injections of a subeffective dose (2.3 pmol) of cortagine, a CRF(1)-selective agonist, resulted in an increase in CCK mRNA levels and CCK(2) receptor immunoreactivity in several brain regions, such as amygdala and hippocampus, known to be involved in the regulation of anxiety. Mice with elevated endogenous central CCK tone exhibited significantly higher anxiety-like behaviors in the open-field task and elevated plus maze, and enhanced conditioned fear. These behavioral changes were reversed by i.c.v. administration of the CCK(2)-selective antagonist LY225910, after 5 days of priming with cortagine. Under the same conditions, the intrap...Continue Reading

References

Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S H HendryP C Emson
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J SpiessW Vale
Aug 1, 1994·Molecular Neurobiology·R F Itzhaki
Apr 1, 1993·Brain Research. Molecular Brain Research·J O WilloughbyS Sagar
Jun 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·J HarroL Oreland
Mar 1, 1997·Journal of Chemical Neuroanatomy·H MezianeB Soumireu-Mourat
Jan 27, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KõksP T Männistö
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·V Daugé, I Léna
Jun 15, 1999·Progress in Neurobiology·F Noble, B P Roques
May 10, 2000·Behavioural Brain Research·M S Fanselow
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Feb 24, 2001·Psychological Review·M E BoutonD H Barlow
Dec 26, 2001·Brain Research. Brain Research Reviews·G D PetrovichL W Swanson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 30, 2003·Cellular and Molecular Neurobiology·Joseph LeDoux
Nov 11, 2003·The Journal of Comparative Neurology·Brian M CainDaesety Vishnuvardham
Mar 12, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yukiko HorinouchiHaruo Nagayama
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Donald G RainnieAnantha Shekhar
Jun 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hossein TezvalJoachim Spiess
Jun 26, 2004·Annual Review of Neuroscience·Joshua A Gordon, Rene Hen
Jul 24, 2004·Molecular Pharmacology·Pieter J PeetersThomas Steckler
Oct 22, 2004·Nature Reviews. Neuroscience·Stephen Maren, Gregory J Quirk

❮ Previous
Next ❯

Citations

Jan 23, 2016·Frontiers in Behavioral Neuroscience·Osnat Hadad-OphirGal Richter-Levin
Apr 27, 2010·Journal of Neuropathology and Experimental Neurology·Takahiro FukudaSaburo Saito
May 15, 2012·Pharmacological Reports : PR·Akbar Hajizadeh MoghaddamAli Roohbakhsh
Oct 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cedomir TodorovicJoachim Spiess
Apr 24, 2009·Journal of Neurophysiology·Leeyup Chung, Scott D Moore
Jun 14, 2017·Reviews in the Neurosciences·Robert Lalonde, Catherine Strazielle
Sep 14, 2018·Frontiers in Endocrinology·Andreas Stengel, Yvette Taché
Jul 10, 2019·Pharmacology & Therapeutics·Marie-Christine TononJérôme Leprince

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Related Papers

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
H J van MegenR S Kahn
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Cristina Ferreira Netto, Francisco Silveira Guimarães
© 2021 Meta ULC. All rights reserved