Chronic stress alters amphetamine effects on behavior and synaptophysin levels in female rats

Pharmacology, Biochemistry, and Behavior
Veronica BisagnoV Luine

Abstract

Previous studies show that stress cross-sensitizes with or alters amphetamine (AMPH) effects in male rats; however, few studies include females. We investigated combining daily restraint stress (21 days for 6 h/day) with chronic AMPH (10 injections every other day) on locomotor activity, exploratory activity in an open field and object recognition, a memory task, in female rats. A synaptic protein, synaptophysin, was also quantified by radioimmunocytochemistry (RICC) in brain to determine possible mechanisms for behavioral changes. Beginning at 5 days after cessation of treatments, AMPH increased locomotion, modified exploration, impaired object recognition, and increased serum corticosterone (CORT) levels. Stress did not alter these parameters but blocked AMPH effects on exploration and object recognition, potentiated AMPH-dependent locomotor effects, and did not alter increased CORT levels. AMPH treatment decreased synatophysin expression in the hippocampus. In the caudate nucleus, the AMPH group showed increased synaptophysin expression which was reversed by stress. These results in females corroborate previously shown cross-sensitizations between stress and AMPH for locomotion in males and demonstrate that chronic stress co...Continue Reading

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Citations

Dec 5, 2008·Psychopharmacology·Christophe PiérardDaniel Béracochéa
Aug 5, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Victoria Luine
Aug 28, 2016·Pharmacology, Biochemistry, and Behavior·Victoria LuineRachel Bowman
Feb 12, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun-Jung ParkInsop Shim
Sep 14, 2007·Journal of Neuroendocrinology·V N LuineN J Maclusky
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun-Jung ParkInsop Shim
Feb 27, 2019·Stress : the International Journal on the Biology of Stress·Farshid EtaeeGhazaleh Omidi

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