Chronic stress differentially regulates glucocorticoid negative feedback response in rats

Psychoneuroendocrinology
Kazushige MizoguchiTakeshi Tabira

Abstract

Exposure to chronic stress is thought to play an important role in the etiology of depression. In this disorder, a disrupted negative feedback response to exogenous glucocorticoids on cortisol secretion has been indicated. However, the regulation of glucocorticoid negative feedback by chronic stress is not fully understood. In the present study, we investigated the effects of chronic stress administered by water immersion and restraint (2 h/day) for four weeks on the glucocorticoid feedback in rats. In the acutely (one-time) stressed rats, the basal plasma corticosterone (CORT) level was markedly elevated, remained at high levels for 5 h after the termination of stress, and then decreased. In the chronically stressed rats, the CORT level was initially elevated similarly, but rapidly decreased at 2 h. In the dexamethasone (DEX) suppression test, the peak CORT level in response to stress was not suppressed by DEX in the acutely stressed rats, but was significantly suppressed in the chronically stressed rats. In contrast, the suppressive effects of DEX on the basal CORT secretion in naive rats were attenuated in the chronically stressed rats. In the chronically stressed hippocampus, which plays an important role in the regulation ...Continue Reading

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Citations

Mar 4, 2009·Psychopharmacology·Ralf RegenthalUte Krügel
Apr 15, 2010·Glycoconjugate Journal·Mayuko IwamotoToshihiko Kadoya
Sep 22, 2011·Neuroscience Bulletin·Ghulam AbbasAhsana Dar
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Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Kazushige MizoguchiTakeshi Tabira
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Kazushige MizoguchiTakeshi Tabira
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Kazushige MizoguchiTakeshi Tabira
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