Chronic stress effects on working memory: association with prefrontal cortical tyrosine hydroxylase

Behavioural Brain Research
Young-A Lee, Yukiori Goto

Abstract

Chronic stress causes deficits in cognitive function including working memory, for which transmission of such catecholamines as dopamine and noradrenaline transmission in the prefrontal cortex (PFC) are crucial. Since catecholamine synthesis depends on the rate-limiting enzyme, tyrosine hydroxylase (TH), TH is thought to play an important role in PFC function. In this study, we found that two distinct population existed in Sprague-Dawley rats in terms of working memory capacity, one with higher working memory capacity, and the other with low capacity. This distinction of working memory capacity became apparent after rats were exposed to chronic stress. In addition, such working memory capacity and alterations of working memory function by chronic stress were associated with TH expression in the PFC.

References

Jun 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J OrtizE J Nestler
May 1, 1997·Brain Research. Molecular Brain Research·S MurruM Pirastu
Jan 1, 1997·Journal of Psychopharmacology·A F Arnsten
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Conor ListonBruce S McEwen
Aug 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hui-Dong Wang, Ariel Y Deutch
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten

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Citations

Feb 13, 2016·Neurochemical Research·Georgina Rodríguez de Lores Arnaiz, Marta C Antonelli
May 2, 2015·Neuroscience and Biobehavioral Reviews·Alexandra Ycaza Herrera, Mara Mather
May 17, 2019·Applied Neuropsychology. Child·Lydia van den BergJaap van der Meere
Sep 19, 2019·Stress : the International Journal on the Biology of Stress·Li LinLiang Zhang

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