Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature.

The Journal of Pharmacology and Experimental Therapeutics
B N Johnson, Bryan K Yamamoto

Abstract

Stress facilitates drug abuse by humans. In rodents, stress enhances the neurochemical, neuroendocrine, and behavioral responses to psychostimulants. Although chronic unpredictable stress (CUS) enhances the acute hyperthermic and long-term monoamine-depleting effects of the psychostimulant +3,4-methylenedioxymethamphetamine (MDMA), the roles of hyperthermia and corticosterone (CORT) in mediating the stress-induced enhancement of MDMA-induced serotonin (5-HT) and dopamine (DA) depletions are unknown. Rats were exposed to 10 days of CUS and then challenged with MDMA (5 mg/kg i.p. once every 2 h for a total of four injections). Prior exposure to CUS augmented MDMA-induced hyperthermia and plasma CORT secretion and the long-term depletions in 5-HT content in striatum, hippocampus, and frontal cortex and DA content in striatum. A reduced ambient temperature of 21°C attenuated the hyperthermia, CORT secretion, and 5-HT decreases after MDMA in nonstressed rats. The lower ambient temperature also prevented the augmented hyperthermia, CORT secretion, and enhanced 5-HT and DA depletions after MDMA in chronically stressed rats to levels exhibited by nonstressed, MDMA-treated rats. To investigate the role of CORT on monoamine depletions in...Continue Reading

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Citations

Nov 2, 2013·Archives of Toxicology·Daniel José BarbosaFélix Carvalho
May 7, 2014·General and Comparative Endocrinology·Dustin A S OwenIgnacio T Moore
Nov 28, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jui-Hu ShihI-Hsun Li
Feb 1, 2011·Behavioural Brain Research·Brittney M CoxShane A Perrine
Sep 29, 2015·Stress : the International Journal on the Biology of Stress·Reka NatarajanBryan K Yamamoto
May 29, 2013·Hearing Research·Michael W ChurchShane A Perrine
Feb 11, 2014·BioMed Research International·Georg F WeberGary A Gudelsky
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May 20, 2015·Molecular and Cellular Biochemistry·G E Mejia-CarmonaA Martínez-Martínez
May 31, 2014·Prague Medical Report·Romana ŠlamberováJana Jurčovičová

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