Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule

Behavioural Pharmacology
Erika BorcelC Venero

Abstract

In this study, we examined whether chronic stress in adulthood can exert long-term effects on spatial-cognitive abilities and on the survival of newborn hippocampal cells in aging animals. Male Wistar rats were subjected to chronic unpredictable stress at midlife (12 months old) and then reexposed each week to a stress stimulus. When evaluated in the water maze at the early stages of aging (18 months old), chronic unpredictable stress accelerated spatial-cognitive decline, an effect that was accompanied by a reduction in the survival of newborn cells and in the number of adult granular cells in the hippocampus. Interestingly, spatial-memory performance in the Morris water maze was positively correlated with the number of newborn cells that survived in the dentate gyrus: better spatial memory in the water maze was associated with more 5-bromo-2-deoxyuridine (BrdU)-labeled cells. Administration of FGL, a peptide mimetic of neural cell adhesion molecule, during the 4 weeks of continuous stress not only prevented the deleterious effects of chronic stress on spatial memory, but also reduced the survival of the newly generated hippocampal cells in aging animals. FGL treatment did not, however, prevent the decrease in the total number...Continue Reading

References

Jun 30, 1994·Annals of the New York Academy of Sciences·A LevyT Kadar
Jul 1, 1996·Stress : the International Journal on the Biology of Stress·R M Sapolsky
Apr 2, 1999·The European Journal of Neuroscience·M F MontaronD N Abrous
Apr 9, 1999·Nature Neuroscience·N M Porter, P W Landfield
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Sep 24, 1999·Nature Neuroscience·H A Cameron, R D McKay
Dec 22, 1999·Biological Psychiatry·E Gould, P Tanapat
Oct 4, 2000·Neurobiology of Aging·J M WyssT van Groen
Nov 7, 2000·Biological Psychiatry·B S McEwen
Nov 21, 2002·Hippocampus·Tracey J ShorsElizabeth Gould
Mar 18, 2003·The Journal of Comparative Neurology·David A MerrillMark H Tuszynski
Jun 20, 2003·The European Journal of Neuroscience·Carmen SandiMichael G Stewart
Jul 16, 2003·The European Journal of Neuroscience·J L Bizon, M Gallagher
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elodie DrapeauDjoher Nora Abrous
Jan 31, 2004·The European Journal of Neuroscience·Vivi M HeinePaul J Lucassen
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karine CambonCarmen Sandi
Jul 27, 2004·Nature Neuroscience·Christian MirescuElizabeth Gould
Nov 20, 2004·Nature Reviews. Neuroscience·Carmen Sandi
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Jun 15, 2005·Neurobiology of Aging·M F MontaronD N Abrous
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Marian JoëlsHarm J Krugers
Oct 4, 2005·The European Journal of Neuroscience·Galina G SkiboElisabeth Bock
Jun 27, 2006·Biological Psychiatry·Alex Dranovsky, René Hen
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elodie DrapeauDjoher Nora Abrous

❮ Previous
Next ❯

Citations

Sep 29, 2011·Psychopharmacology·Kamilla W MiskowiakLars V Kessing
Dec 17, 2009·Molecular Psychiatry·V K PariharA K Shetty
Jul 20, 2010·International Journal of Molecular Sciences·Shizhong LiVladimir Berezin
Oct 19, 2012·Neurochemical Research·Bunmi OjoMichael G Stewart
Mar 8, 2011·Neurobiology of Learning and Memory·Marie-France MarinSonia J Lupien
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Melly S OitzlE Ronald de Kloet
Jul 31, 2012·Neurobiology of Disease·Maj N EnevoldsenElisabeth Bock
Mar 9, 2012·Current Opinion in Neurobiology·Shira Knafo, José A Esteban
Mar 26, 2015·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jieun SongMargie E Lachman
Feb 11, 2015·Neurobiology of Aging·Daniela PuzzoAgostino Palmeri
Jun 5, 2014·Psychopharmacology·R SeigersS B Schagen
Jul 2, 2016·Nutrition Research Reviews·Christine Heberden
Apr 29, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cortney A TurnerHuda Akil
Jun 13, 2019·Stress : the International Journal on the Biology of Stress·Damien HuzardCarmen Sandi
Jul 14, 2018·Neurochemical Research·Chengyan ChuShen Li
Jan 1, 2011·Dementia & Neuropsychologia·Juliana Nery de Souza-TalaricoSonia J Lupien
Feb 14, 2020·International Journal of Molecular Sciences·Dolors Puigoriol-IllamolaMercè Pallàs
May 29, 2021·Translational Psychiatry·María Calleja-FelipeShira Knafo
May 13, 2009·Current Opinion in Lipidology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.