Chronic Stress Induces Brain Region-Specific Alterations of Molecular Rhythms that Correlate with Depression-like Behavior in Mice

Biological Psychiatry
Ryan W LoganColleen A McClung

Abstract

Emerging evidence implicates circadian abnormalities as a component of the pathophysiology of major depressive disorder (MDD). The suprachiasmatic nucleus (SCN) of the hypothalamus coordinates rhythms throughout the brain and body. On a cellular level, rhythms are generated by transcriptional, translational, and posttranslational feedback loops of core circadian genes and proteins. In patients with MDD, recent evidence suggests reduced amplitude of molecular rhythms in extra-SCN brain regions. We investigated whether unpredictable chronic mild stress (UCMS), an animal model that induces a depression-like physiological and behavioral phenotype, induces circadian disruptions similar to those seen with MDD. Activity and temperature rhythms were recorded in C57BL/6J mice before, during, and after exposure to UCMS, and brain tissue explants were collected from Period2 luciferase mice following UCMS to assess cellular rhythmicity. UCMS significantly decreased circadian amplitude of activity and body temperature in mice, similar to findings in MDD patients, and these changes directly correlated with depression-related behavior. While amplitude of molecular rhythms in the SCN was decreased following UCMS, surprisingly, rhythms in the n...Continue Reading

References

Jul 1, 1994·Journal of Psychiatric Research·I HeuserF Holsboer
May 1, 1996·Pharmacology, Biochemistry, and Behavior·Z GorkaM Papp
Apr 29, 1998·Journal of Biological Rhythms·D R Weaver
Mar 15, 2000·Reviews in the Neurosciences·R D Porsolt
Jun 19, 2002·Journal of Psychosomatic Research·Ania KorszunLeslie A Crofford
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Feb 20, 2004·Brain Research·Ozgür TataroğluResit Canbeyli
Feb 24, 2004·Critical Reviews in Neurobiology·Philip V Holmes
Dec 21, 2004·Psychopharmacology·Benoit Petit-DemouliereMichel Bourin
Mar 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Elaine Waddington LamontShimon Amir
Sep 6, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jolanda TumaJaap M Koolhaas
Aug 24, 2006·The Journal of Comparative Neurology·Michelle Y ChengQun-Yong Zhou
Sep 22, 2006·Human Molecular Genetics·Caroline H Ko, Joseph S Takahashi
Oct 7, 2006·Behavioural Brain Research·Yann S MineurWim E Crusio
Mar 31, 2007·Pharmacology & Therapeutics·Colleen A McClung
Jan 25, 2008·The European Journal of Neuroscience·Alice H LuoGary S Aston-Jones
Jul 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Palmiero Monteleone, Mario Maj
Feb 10, 2009·The European Journal of Neuroscience·Alice H Luo, Gary Aston-Jones
May 2, 2009·Psychoneuroendocrinology·Nestor L Lopez-DuranCharles J George
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alex Y -L SoBrian J Feldman
Jun 26, 2010·The Journal of Clinical Investigation·Silke KiesslingHenrik Oster
May 4, 2011·Molecular Psychiatry·A SurgetC Belzung
Aug 30, 2011·Neuropharmacology·Noga Kronfeld-Schor, Haim Einat
Sep 16, 2011·Expert Opinion on Pharmacotherapy·Regina M Carney, Richard C Shelton
Jan 5, 2012·Journal of Biological Rhythms·Anne-Sofie JohanssonGabriella B S Lundkvist
Sep 27, 2012·Journal of Biological Rhythms·Michael J McCarthy, David K Welsh
Oct 9, 2012·The European Journal of Neuroscience·Sade SpencerColleen A McClung
Feb 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carla S Möller-LevetDerk-Jan Dijk

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Citations

Jan 23, 2016·Frontiers in Psychiatry·Puja K Parekh, Colleen A McClung
Jan 9, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Francesca CalabreseMarco A Riva
Sep 9, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Pawan Kumar MauryaElisa Brietzke
May 31, 2015·Behavioural Brain Research·Nabarun ChakrabortyMarti Jett
Jul 2, 2016·The International Journal of Neuropsychopharmacology·S L ChristiansenO Wiborg
Sep 7, 2016·EBioMedicine·Timo Partonen
Sep 7, 2016·Chronobiology International·Yasmine M CisséRandy J Nelson
Apr 5, 2018·Journal of Biological Rhythms·Amanda R LibermanKrista K Ingram
Dec 27, 2017·PsyCh Journal·Charlotte Helfrich-Förster
Dec 11, 2017·Biomolecules & Therapeutics·Mikyung KimHee Jin Kim
Oct 23, 2018·Annals of the New York Academy of Sciences·Laura E WebbMargit Bak Jensen
Sep 29, 2018·Annals of Medicine·Anisja HühneDominic Landgraf
Nov 8, 2018·The European Journal of Neuroscience·Kyle D KetchesinColleen A McClung
Feb 26, 2016·F1000Research·Darius Becker-Krail, Colleen McClung
Nov 6, 2018·Acta Biochimica Et Biophysica Sinica·Lingyan MaZhengwei Fu
Jan 12, 2019·The European Journal of Neuroscience·Jodi R PaulKaren L Gamble
Sep 14, 2018·Journal of Circadian Rhythms·Hiroshi KawaiAtsushi Mitsumoto
Jul 31, 2019·Journal of Neurochemistry·Dietrich van CalkerTsvetan Serchov
Dec 13, 2017·Neural Plasticity·Chelsea A Vadnie, Colleen A McClung
Jan 23, 2020·Acta Physiologica·Kimberly BegemannHenrik Oster
Nov 23, 2017·Stress : the International Journal on the Biology of Stress·Lauren E ChunRobert L Spencer
Feb 23, 2017·Frontiers in Neuroscience·Aurea Blancas-VelazquezSusanne E la Fleur
Aug 1, 2018·Scientific Reports·Luísa K PilzMaria Paz Hidalgo
Jun 1, 2016·Molecular Psychiatry·M T Treadway, C V Leonard
Jun 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alessandra PorcuDavid K Welsh
Feb 13, 2020·Frontiers in Psychiatry·Agorastos AgorastosPanagiota Pervanidou
Nov 22, 2016·Nature·Tobias S KaiserKristin Tessmar-Raible
Apr 4, 2017·Neural Plasticity·Malgorzata Jasinska, Elzbieta Pyza
Nov 23, 2017·Frontiers in Molecular Neuroscience·Angela R OzburnColleen A McClung
Sep 14, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jaqueline B SchuchLuciana Tovo-Rodrigues
Jan 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mathieu NolletRaphaelle Winsky-Sommerer
Jan 17, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francisco Borja BellochRosa María Tordera

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