Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin alpha5 expression in the rat pineal gland

Brain Research
Alexies Dagnino-SubiabreFrancisco Aboitiz

Abstract

Chronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. Moreover, stress induces deleterious actions on the epithalamic pineal organ, a gland involved in a wide range of physiological functions. The aim of this study was to investigate whether the stress effects on the pineal gland are related with changes in the expression of neurotrophic factors and cell adhesion molecules. Using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, we analyzed the effect of chronic immobilization stress on the BDNF mRNA and integrin alpha5 expression in the rat pineal gland. We found that BDNF is produced in situ in the pineal gland. Chronic immobilization stress induced upregulation of BDNF mRNA and integrin alpha5 expression in the rat pineal gland but did not produce changes in beta-actin mRNA or in GAPDH expression. Stressed animals also evidenced an increase in anxiety-like behavior and acute gastric lesions. These results suggest that BDNF and integrin alpha5 may have a counteracting effect to the deleterious actions of immobilization stress on functionally stimulated pinealocytes. Furthermor...Continue Reading

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Citations

Feb 18, 2009·Anatomical Science International·Michihiro KurushimaTakashi Kachi
Nov 9, 2012·International Journal of Medical Sciences·Seok Joon ShinDai-Jin Kim
Apr 29, 2009·Behavioural Brain Research·Alexies Dagnino-SubiabreFrancisco Aboitiz
Dec 18, 2008·The European Journal of Neuroscience·Céline A FeilletEtienne Challet
Feb 15, 2012·Brain Research·Olena BabenkoGerlinde A Metz
Mar 10, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michail PavlidisAleka Tsalafouta
Oct 5, 2010·Neuroscience and Biobehavioral Reviews·Karen Wager-Smith, Athina Markou
Jun 30, 2009·Biological Psychiatry·Stefania SchiavoneKarl-Heinz Krause
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bombi LeeDae-Hyun Hahm
Oct 28, 2019·Environmental Toxicology and Chemistry·Manoochehr KhazaeeCarla A Ng
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