Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man

Neurobiology of Learning and Memory
Lars SchwabeMelly S Oitzl

Abstract

Acute stress modulates multiple memory systems in favor of caudate nucleus-dependent stimulus-response and at the expense of hippocampus-dependent spatial learning and memory. We examined in mice and humans whether chronic stress has similar consequences. Male C57BL/6J mice that had been repeatedly exposed to rats ("rat stress") used in a circular hole board task significantly more often a stimulus-response strategy (33%) than control mice (0%). While velocity was increased, differences in latency to exit hole, distance moved or number of holes visited were not observed. Increased velocity and performance during retention trials one day later indicates altered emotionality and motivation to explore in rat stressed mice. Forty healthy young men and women were split into "high chronic stress" and "low chronic stress" groups based on their answers in a chronic stress questionnaire ("Trier Inventory of Chronic Stress"-TICS) and trained in a 2D task. A test trial immediately after training revealed that participants of the "high chronic stress" group used the S-R strategy significantly more often (94%) than participants of the "low chronic stress" group (52%). Verbal self-reports confirmed the strategy derived from participants' cho...Continue Reading

References

Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·M J MeaneyR M Sapolsky
Sep 6, 1996·Science·B J KnowltonL R Squire
Dec 24, 1997·Psychological Medicine·R PurcellC Pantelis
Mar 13, 1998·Annual Review of Psychology·J D Gabrieli
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Nov 27, 1999·Science·M S JogA M Graybiel
Nov 28, 2001·Journal of Neuroendocrinology·G Blackburn-Munro, R E Blackburn-Munro
Aug 21, 2002·Stress : the International Journal on the Biology of Stress·Victoria Luine
Nov 30, 2002·Neuropsychologia·Russell A Poldrack, Mark G Packard
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
May 5, 2004·Psychological Bulletin·Sally S Dickerson, Margaret E Kemeny
Oct 2, 2004·Journal of Psychiatric Research·P O HarveyP Fossati
Oct 7, 2004·Neurobiology of Learning and Memory·Larry R Squire
Oct 7, 2004·Neurobiology of Learning and Memory·Mark G Packard, Jeffrey C Wingard
Oct 7, 2004·Neurobiology of Learning and Memory·Sheri J Y MizumoriDenise M Davis
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rupshi MitraSumantra Chattarji
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Ryan L Wright, Cheryl D Conrad
Oct 4, 2005·The American Journal of Psychiatry·Jorge L ArmonyAlain Brunet
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Eberhard FuchsBoldizsar Czeh
Jul 4, 2006·Behavioral and Cognitive Neuroscience Reviews·Cheryl D Conrad
Jul 15, 2006·Journal of Cognitive Neuroscience·K SchiltzE Düzel
Feb 3, 2007·Learning & Memory·Lars SchwabeHartmut Schachinger
Jun 5, 2007·Trends in Molecular Medicine·Michael J MeaneyJonathan R Seckl
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Véronique D BohbotAlex P Zijdenbos
Apr 16, 2008·Behavioral Neuroscience·Gwendolyn E WoodBruce S McEwen
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Myoung-Hwan KimEunjoon Kim

❮ Previous
Next ❯

Citations

Aug 5, 2009·Molecular Neurobiology·Katie J McLaughlinCheryl D Conrad
Apr 1, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Kristiaan B van der HeijdenLeo M J de Sonneville
May 19, 2009·Journal of Cognitive Neuroscience·Lars SchwabeMelly S Oitzl
Nov 25, 2011·Cellular and Molecular Neurobiology·J P ter HorstM S Oitzl
Jul 2, 2014·Neurobiology of Learning and Memory·Antonella GasbarriCarlos Tomaz
Feb 10, 2016·Frontiers in Psychology·Smarandita CeccatoChristiane Schwieren
Jan 8, 2013·Trends in Cognitive Sciences·Lars Schwabe, Oliver T Wolf
May 1, 2012·Neurobiology of Learning and Memory·J P ter HorstM S Oitzl
Jul 21, 2011·Neuroscience and Biobehavioral Reviews·Lars SchwabeMelly S Oitzl
Jan 12, 2011·Behavioural Brain Research·Lars Schwabe, Oliver T Wolf
Apr 2, 2016·Neural Plasticity·Deborah Ness, Pasquale Calabrese
Apr 28, 2010·Behavioural Brain Research·Lars SchwabeMelly S Oitzl
Apr 13, 2010·Psychoneuroendocrinology·Marian Joëls
Mar 5, 2016·Frontiers in Psychiatry·Jarid Goodman, Mark G Packard
Nov 26, 2009·Neuroscience and Biobehavioral Reviews·Lars SchwabeMelly S Oitzl
Nov 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cheryl D Conrad
Sep 16, 2009·Pharmacology, Biochemistry, and Behavior·Ebany J Martinez-FinleyAndrea M Allan
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Melly S OitzlE Ronald de Kloet
Jul 15, 2009·Progress in Neurobiology·Jacques EpelbaumCécile Viollet
Aug 10, 2013·Hippocampus·Mark G Packard, Jarid Goodman
Jun 21, 2015·Neurobiology of Learning and Memory·Jarid Goodman, Mark G Packard
May 19, 2012·Hippocampus·Lars SchwabeOliver T Wolf
May 1, 2013·Wiley Interdisciplinary Reviews. Cognitive Science·Carmen Sandi
Apr 21, 2009·Brain Research·Oliver T Wolf
Dec 12, 2012·Behavioural Brain Research·J P ter HorstM S Oitzl
Apr 27, 2012·Stress : the International Journal on the Biology of Stress·Wayne R HawleyGary P Dohanich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.