Chronic stress produces enduring decreases in novel stress-evoked c-fos mRNA expression in discrete brain regions of the rat.

Stress : the International Journal on the Biology of Stress
Michelle M OstranderJames P Herman

Abstract

Chronic stress produces numerous adaptations within the hypothalamic-pituitary-adrenal (HPA) axis that persist well after cessation of chronic stress. We previously demonstrated profound attenuation of HPA axis responses to novel environment 4-7 days following chronic stress. The present study tests the hypothesis that this HPA axis hyporesponsivity is associated with reductions in stress-evoked c-fos mRNA expression, a marker of neuronal activation, in discrete brain regions. Adult male Sprague-Dawley rats underwent 1 week of chronic variable stress (CVS), with unhandled rats serving as controls. Independent groups of control and CVS rats were exposed to novel environment at 16 h, 4 days, 7 days, or 30 days after CVS. Marked reductions of c-fos mRNA expression in the CVS group persisted for at least 30 days within the paraventricular nucleus of the hypothalamus, and for at least 1 week in rostroventrolateral septum and lateral hypothalamus. Lower levels of c-fos mRNA expression were observed at 16 h recovery in the ventrolateral medial preoptic area, basolateral amygdala, anterior cingulate cortex, and prelimbic cortex. The results demonstrate long-term alterations in neuronal activation within neurocircuits critical for regul...Continue Reading

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Citations

Aug 19, 2011·Psychopharmacology·Howard C BeckerTamara L Doremus-Fitzwater
Dec 14, 2011·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Michael J McFarlandPatricia A Thomas
Jan 24, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Stacey B ScottLindsay Pitzer
Dec 19, 2013·Behavioral and Brain Functions : BBF·Jia LuoFeng Jin
Nov 16, 2016·Frontiers in Endocrinology·James P Herman, Jeffrey G Tasker
Aug 26, 2018·Journal of Neuroscience Research·Jana OsackaAlexander Kiss
Jun 1, 2021·Brain, Behavior, and Immunity·Tobias T PohlOliver J Bosch

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