Abstract
Chronic stress was previously reported to play a role in the development of oral cancer, yet the correlation between stressors and oral cancer progression is not well understood. We implanted human oral cancer cell line CAL 27 in nude mice to investigate the effects of chronic stress on tumor growth, and designed a physical restraint system to create an experimentally stressed animal model, in which periodic immobilization induced characteristic chronic stress. Tumor burdened animal were randomly assigned into four groups: (a) control group, (b) daily stress for 2h with light, (c) daily stress for 2h in dark, and (d) daily stress for 6h with light. Animals were sacrificed after three weeks. Various analyses were performed on parameters including body weight, tumor weight, in situ expression of MMP-2 and VEGF, and the plasma concentrations of epinephrine, norepinephrine and glucocorticoid. Our data showed that chronic stress resulted in greater tumor size, more expression of MMP-2 and VEGF, higher level of plasma catecholamines, and more invasive growth of oral carcinoma cells in a mice model. We have successfully set up an animal model, which studied the effect of chronic stress on oral carcinoma growth rate and progression. Th...Continue Reading
References
Apr 4, 1998·Journal of Neuroimmunology·Nora TarcicJoseph Weidenfeld
May 21, 1999·Physiology & Behavior·L R KerrJ Weinberg
Jan 5, 2002·Head & Neck·D ThurnherJ Kornfehl
Sep 5, 2002·Cancer·Susan K LutgendorfAnil K Sood
Nov 18, 2005·Journal of Neuroimmunology·Ratna BiswasUtpala Chattopadhyay
Jul 25, 2006·Nature Medicine·Premal H ThakerAnil K Sood
Aug 25, 2007·The Journal of Biological Chemistry·Monique B NilssonAnil K Sood
Jun 14, 2008·Brain, Behavior, and Immunity·Susan K LutgendorfSteve W Cole
Nov 11, 2008·Brain, Behavior, and Immunity·Eric V YangRonald Glaser
Mar 3, 2009·Oral Oncology·Shu-Ching ChenYeur-Hur Lai
Sep 14, 2010·Experimental Gerontology·Greti Aguilera
Oct 20, 2010·Brain, Behavior, and Immunity·Susan K LutgendorfSteve W Cole
Oct 26, 2010·European Journal of Cell Biology·Mercedes ReyPhilippe Chavrier
Dec 29, 2010·Brain, Behavior, and Immunity·Daniel G BernabéSandra H P Oliveira
Apr 18, 2012·Cancer Research·Basel SitohyHarold F Dvorak
Jan 19, 2013·Science·Jacques BarikFrançois Tronche
May 10, 2013·Bulletin of Experimental Biology and Medicine·D A MoshkovL L Pavlik
Dec 21, 2013·Cancer Metastasis Reviews·Benoît ThibaultBettina Couderc
Feb 1, 2014·Journal of Clinical Anesthesia·Juan P CataVijaya Gottumukkala
Mar 13, 2014·Hormones & Cancer·Masis IsikbayRussell Z Szmulewitz
Apr 2, 2014·The European Journal of Neuroscience·Melanie Y Vincent, Lauren Jacobson
Jul 23, 2014·PloS One·Huixu XieLongjiang Li
Oct 11, 2014·Neuroendocrinology·Keiko ArakawaTerrence Deak
Citations
Jan 23, 2016·Oral Oncology·Rahul AnandSachin C Sarode
Jul 12, 2016·Stress : the International Journal on the Biology of Stress·O KrizanovaK Pacak
Mar 5, 2018·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nyanbol KuolKulmira Nurgali
Aug 21, 2018·PloS One·Daniela B BastosDaniel G Bernabé
Dec 5, 2018·Molecular Reproduction and Development·Abulizi KeremuXiamixinuer Yilike
Feb 27, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ye ZhangHonglu Wu
Oct 3, 2018·International Journal of Oncology·Zhaozhou ZhangQi Li
Jul 16, 2020·Investigative and Clinical Urology·Shiyu MaoXudong Yao
Sep 28, 2020·Cancer Chemotherapy and Pharmacology·Heitor Pinhata CecilioDaniel Galera Bernabé
Jun 20, 2020·Journal of Molecular Histology·Gordana SmieškoDušan Lalošević
Sep 17, 2020·Cell Death & Disease·Peixin DuXuelei Ma
Nov 13, 2020·Frontiers in Oncology·Ping WangJunhong Dong
Jan 8, 2021·PloS One·Flávia Alves VerzaDaniel Galera Bernabé
Apr 3, 2020·Archives of Oral Biology·Bowen ZhangLongjiang Li
Jan 1, 2021·Psychology Research and Behavior Management·Qidong ZhouKe Xu
Jan 10, 2021·Cancers·Anem IftikharIan Ellis
Apr 15, 2021·Molecular Therapy. Nucleic Acids·Xiaofang ZhouJie Tang
May 1, 2021·Brain Sciences·Qian ZhouKagaku Azuma
Jun 22, 2021·Cancer Investigation·Qidong ZhouKe Xu
Jul 3, 2021·Cancers·Maria-Bernadette Madel, Florent Elefteriou
Aug 18, 2020·Archives of Oral Biology·Diego Mauricio Bravo-CalderónDenise Tostes Oliveira
Oct 7, 2021·Scientific Reports·Vitor Bonetti ValenteDaniel Galera Bernabé