Chronic stress promotes oral cancer growth and angiogenesis with increased circulating catecholamine and glucocorticoid levels in a mouse model

Oral Oncology
Huixu XieLongjiang Li

Abstract

Chronic stress was previously reported to play a role in the development of oral cancer, yet the correlation between stressors and oral cancer progression is not well understood. We implanted human oral cancer cell line CAL 27 in nude mice to investigate the effects of chronic stress on tumor growth, and designed a physical restraint system to create an experimentally stressed animal model, in which periodic immobilization induced characteristic chronic stress. Tumor burdened animal were randomly assigned into four groups: (a) control group, (b) daily stress for 2h with light, (c) daily stress for 2h in dark, and (d) daily stress for 6h with light. Animals were sacrificed after three weeks. Various analyses were performed on parameters including body weight, tumor weight, in situ expression of MMP-2 and VEGF, and the plasma concentrations of epinephrine, norepinephrine and glucocorticoid. Our data showed that chronic stress resulted in greater tumor size, more expression of MMP-2 and VEGF, higher level of plasma catecholamines, and more invasive growth of oral carcinoma cells in a mice model. We have successfully set up an animal model, which studied the effect of chronic stress on oral carcinoma growth rate and progression. Th...Continue Reading

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Citations

Jul 12, 2016·Stress : the International Journal on the Biology of Stress·O KrizanovaK Pacak
Mar 5, 2018·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nyanbol KuolKulmira Nurgali
Feb 27, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ye ZhangHonglu Wu
Oct 3, 2018·International Journal of Oncology·Zhaozhou ZhangQi Li
Sep 28, 2020·Cancer Chemotherapy and Pharmacology·Heitor Pinhata CecilioDaniel Galera Bernabé
Jun 20, 2020·Journal of Molecular Histology·Gordana SmieškoDušan Lalošević
Jan 8, 2021·PloS One·Flávia Alves VerzaDaniel Galera Bernabé
Jan 1, 2021·Psychology Research and Behavior Management·Qidong ZhouKe Xu
Aug 18, 2020·Archives of Oral Biology·Diego Mauricio Bravo-CalderónDenise Tostes Oliveira
Oct 7, 2021·Scientific Reports·Vitor Bonetti ValenteDaniel Galera Bernabé

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