Chronic stress regulates NG2⁺ cell maturation and myelination in the prefrontal cortex through induction of death receptor 6

Experimental Neurology
Youjun YangBaoming Li

Abstract

Chronic stress significantly affects neuron morphometry and function in the prefrontal cortex, a brain region controlling cognition and emotion. However, whether and how chronic stress regulates the maturation of NG2-expressing oligodendrocyte precursor cell (NG2(+) cell) and the importance of these changes remained unknown. Here, we report that exposing adult mice to chronic stress results in NG2(+) cell atrophy and myelination arrested in the medial prefrontal cortex (mPFC), and impaired mPFC-dependent functions. These alterations, are phenocopied by overexpression of death receptor 6 (DR6) in NG2(+) cell. Conversely, selectively silencing of DR6 in the NG2(+) cell can partly rescue NG2(+) cell atrophy and cognitive deficiency caused by chronic stress. We further demonstrate that myelination appears necessary for mPFC-dependent cognitive processes, as lysolecithin (LPC)-induced demyelination specifically in the mPFC is sufficient to cause these behavioral and cognitive impairments. Our results indicate that chronic stress impairs cognitive functions, at least in part, through modulation of NG2(+) cell maturation and myelination, and suggest that myelination is require for normal cognitive functions.

References

Aug 4, 1998·European Journal of Biochemistry·K Schulze-OsthoffM E Peter
Jan 18, 2003·Psychological Reports·Deborah A Yurgelun-ToddAshley D Young
Aug 24, 2005·Nature Neuroscience·Sara L BengtssonFredrik Ullén
Nov 12, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·R Douglas Fields
Mar 21, 2006·The Journal of Biological Chemistry·Claudia BossenPascal Schneider
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Conor ListonBruce S McEwen
Jul 17, 2007·Neuroscience Letters·Federica LocchiRoberto Rimondini
Jun 10, 2008·Trends in Neurosciences·R Douglas Fields
Oct 14, 2008·Nature Neuroscience·Leanne E RiversWilliam D Richardson
Oct 22, 2008·Nature Reviews. Neuroscience·Robin J M Franklin, Charles Ffrench-Constant
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
Aug 1, 2009·Science·Eduardo Dias-FerreiraNuno Sousa
Mar 11, 2010·Nature Reviews. Neuroscience·Klaus-Armin Nave
Mar 31, 2010·Annual Review of Neuroscience·Chad E Forbes, Jordan Grafman
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richa B TripathiWilliam D Richardson
May 26, 2011·Neuron·William D RichardsonIan McKenzie
Jul 28, 2012·Journal of Molecular Neuroscience : MN·Pawel LisowskiArtur H Swiergiel
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Daniel J MillerChet C Sherwood
Nov 13, 2012·Nature Neuroscience·Jia LiuPatrizia Casaccia
Dec 25, 2012·Neuron·David R EustonBruce L McNaughton
Mar 12, 2013·Neuron·Kaylene M YoungWilliam D Richardson
Jul 25, 2014·Glia·V HaroutunianG Bartzokis
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Klaus-Armin Nave, Hauke B Werner
Oct 18, 2014·Science·Ian A McKenzieWilliam D Richardson
Nov 25, 2014·Cell·Maggie S Y YeungJonas Frisén
Apr 8, 2015·Nature Neuroscience·Jacob H HinesBruce Appel

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Citations

Apr 19, 2017·Scientific Reports·Michael L LehmannMiles Herkenham
Aug 7, 2017·Journal of Cellular and Molecular Medicine·Malgorzata Ziemka-NaleczJoanna Sypecka
Apr 26, 2018·Neural Plasticity·Mara Nickel, Chen Gu
Apr 3, 2021·Neurobiology of Stress·Nicole Oldham GreenIrina Voineagu

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