Chronic subordinate colony housing paradigm: a mouse model to characterize the consequences of insufficient glucocorticoid signaling

Frontiers in Psychiatry
Dominik LanggartnerStefan O Reber

Abstract

Chronic, in particular chronic psychosocial, stress is a burden of modern societies and known to be a risk factor for numerous somatic and affective disorders (in detail referenced below). However, based on the limited existence of appropriate, and clinically relevant, animal models for studying the effects of chronic stress, the detailed behavioral, physiological, neuronal, and immunological mechanisms linking stress and such disorders are insufficiently understood. To date, most chronic stress studies in animals employ intermittent exposure to the same (homotypic) or to different (heterotypic) stressors of varying duration and intensity. Such models are only of limited value, since they do not adequately reflect the chronic and continuous situation that humans typically experience. Furthermore, application of different physical or psychological stimuli renders comparisons to the mainly psychosocial stressors faced by humans, as well as between the different stress studies almost impossible. In contrast, rodent models of chronic psychosocial stress represent situations more akin to those faced by humans and consequently seem to hold more clinical relevance. Our laboratory has developed a model in which mice are exposed to soci...Continue Reading

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Citations

May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stefan O ReberChristopher A Lowry
Aug 16, 2016·Brain, Behavior, and Immunity·Daniel PeterlikNicole Uschold-Schmidt
Oct 30, 2016·Stress : the International Journal on the Biology of Stress·Dominik LanggartnerStefan O Reber
Feb 23, 2017·Psychopharmacology·D A Slattery, J F Cryan
Jan 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Nathan J KleistClinton D Francis
Nov 18, 2017·Scientific Reports·Sandra FoertschStefan O Reber
Oct 7, 2017·Disease Models & Mechanisms·Sandra FoertschAnita Ignatius
Nov 6, 2018·Pflügers Archiv : European journal of physiology·Dominik LanggartnerStefan O Reber
May 11, 2018·Stress : the International Journal on the Biology of Stress·Marianela Masis-CalvoInga D Neumann
May 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Till S BöbelStefan O Reber
Apr 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Melanie Haffner-LuntzerStefan O Reber
Nov 23, 2018·Frontiers in Behavioral Neuroscience·Dominik LanggartnerStefan O Reber

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