Chronic systemic administration of 5-HT produces weight loss in mature adult male rats

Physiology & Behavior
S Edwards

Abstract

Adult male rats were allowed to free-feed until their body weights had stabilised. They were next trained onto a 4 h per day feeding regimen, until further stabilisation occurred. All rats then received saline injections for 5 days, to establish baseline body weights. One group was then injected with 5.0 mg/kg 5-HT daily for 30 days while the other group continued with saline. Progressive and significant weight loss occurred in the drug-treated animals. After 30 days, the 5-HT-treated rats had lost 7.0% of their baseline body weights, whereas the control group had gained 1.3%. At this point, the 5-HT treated rats were switched back to saline injections to investigate rebound effects. Although the group that had received 5-HT treatment showed evidence of rebound weight gain, mean weights at the end of the 10 day rebound period were still 4.5% lower than baseline values. These data clearly indicate that chronic systemic administration of 5-HT can produce considerable weight loss in rats.

References

Nov 1, 1976·Annals of Surgery·J M Kellum, B M Jaffe
Apr 1, 1978·British Journal of Pharmacology·B V ClineschmidtJ A Totaro
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·K Eberle-Wang, K J Simansky
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·S Edwards, R G Stevens
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·P J Fletcher, M J Burton
Jun 1, 1985·Physiology & Behavior·P J Fletcher, M J Burton
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P J Fletcher, M J Burton
Aug 1, 1981·Pharmacology, Biochemistry, and Behavior·J D Pollock, N Rowland
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·S Edwards, R Stevens

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Citations

Jul 24, 2003·Family Practice·Mary D SammelMichelle Battistini

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