Abstract
Angiopoietin-2 has been implicated in the angiogenic response; however, this response has been tied to the expression of VEGF, and an independent angiogenic role has yet to be described. In this report, we detail the generation of transgenic mice that conditionally express angiopoietin-2 in the liver, resulting in sustained increases in circulating levels. These animals survive gestation and present with several vascular abnormalities, including an increase in the diameter of myocardial coronary vessels and a reduction in the density of endocardial vessels. In the lung, prominent increases in vessel diameter were observed. These vascular remodeling changes occurred in the absence of any apparent increase in VEGF expression. Our results illustrate that chronic systemic delivery of angiopoietin-2 induces angiogenesis in the absence of increased VEGF expression and that angiopoietin-2 promotes myocardial coronary vessel remodeling.
References
Aug 15, 1994·Genes & Development·D J DumontM L Breitman
Nov 1, 1994·The American Journal of Physiology·E HashimotoY Kira
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N SatoK L Audus
Apr 4, 1996·Nature·P CarmelietA Nagy
Apr 4, 1996·Nature·N FerraraM W Moore
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·A KistnerH Bujard
Dec 27, 1996·Cell·C SuriG D Yancopoulos
Jul 4, 1997·Science·P C MaisonpierreG D Yancopoulos
Oct 9, 1998·Oncogene·N Jones, D J Dumont
Feb 2, 1999·The Journal of Clinical Investigation·S TanakaJ R Wands
May 26, 1999·Transgenic Research·R Sarao, D J Dumont
Jun 18, 1999·Science·J HolashS J Wiegand
Jun 15, 2000·The American Journal of Pathology·L F BrownG D Yancopoulos
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Feb 13, 2001·Cardiovascular Research·K Teichert-KuliszewskaD J Stewart
Aug 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ivan B LobovRichard A Lang
Oct 4, 2002·Developmental Cell·Nicholas W GaleGeorge D Yancopoulos
Mar 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Toshiro MatsunagaWilliam M Chilian
Mar 16, 2004·Circulation Research·Robin N N HanDuncan J Stewart
Jul 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hyuek Jong LeeGou Young Koh
Aug 11, 2004·Circulation·Kaeng W LeeAndrew D Blann
Aug 28, 2004·The American Journal of Pathology·Nicole L WardDaniel J Dumont
Nov 16, 2004·Cancer Cell·Jonathan OlinerRichard Kendall
Citations
Feb 9, 2007·Journal of Virology·Feng-Chun YeShou-Jiang Gao
Dec 20, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jian-Xiong ChenBarbara Meyrick
Aug 4, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sarah L TresselHanjoong Jo
Jan 25, 2012·PloS One·Sophie CalderariEtienne Larger
Mar 8, 2013·PloS One·Fan-Chi ChangShuei-Liong Lin
Sep 22, 2009·Journal of Theoretical Biology·Dominik SzczerbaGabor Szekely
Oct 24, 2007·Life Sciences·Subir Kumar Das, D M Vasudevan
May 2, 2012·Developmental Biology·Qing CaiAlvin C Powers
Apr 27, 2016·Children and Youth Services Review·Irwin Garfinkel, Afshin Zilanawala
May 30, 2016·BMC Research Notes·Annie BourdeauDaniel J Dumont
Aug 23, 2016·The Journal of Clinical Investigation·Minah KimDonald M McDonald
Jun 2, 2007·Circulation Research·Yvonne ReissKarl H Plate
Jun 17, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Xiong Chen, Amanda Stinnett
Jul 13, 2007·Journal of the American Society of Nephrology : JASN·Belinda DavisLuigi Gnudi
Apr 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qin-Hui TuoJian-Xiong Chen
Jan 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew JohnstonNicole L Ward
Mar 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seth B CoffeltClaire E Lewis
Jun 10, 2010·Cancer Research·Seth B CoffeltClaire E Lewis