Chronic systemic delivery of angiopoietin-2 reveals a possible independent angiogenic effect

American Journal of Physiology. Heart and Circulatory Physiology
W BureauD J Dumont

Abstract

Angiopoietin-2 has been implicated in the angiogenic response; however, this response has been tied to the expression of VEGF, and an independent angiogenic role has yet to be described. In this report, we detail the generation of transgenic mice that conditionally express angiopoietin-2 in the liver, resulting in sustained increases in circulating levels. These animals survive gestation and present with several vascular abnormalities, including an increase in the diameter of myocardial coronary vessels and a reduction in the density of endocardial vessels. In the lung, prominent increases in vessel diameter were observed. These vascular remodeling changes occurred in the absence of any apparent increase in VEGF expression. Our results illustrate that chronic systemic delivery of angiopoietin-2 induces angiogenesis in the absence of increased VEGF expression and that angiopoietin-2 promotes myocardial coronary vessel remodeling.

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Citations

Dec 20, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jian-Xiong ChenBarbara Meyrick
Aug 4, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sarah L TresselHanjoong Jo
Jan 25, 2012·PloS One·Sophie CalderariEtienne Larger
Sep 22, 2009·Journal of Theoretical Biology·Dominik SzczerbaGabor Szekely
Oct 24, 2007·Life Sciences·Subir Kumar Das, D M Vasudevan
Apr 27, 2016·Children and Youth Services Review·Irwin Garfinkel, Afshin Zilanawala
Aug 23, 2016·The Journal of Clinical Investigation·Minah KimDonald M McDonald
Jun 2, 2007·Circulation Research·Yvonne ReissKarl H Plate
Jun 17, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Xiong Chen, Amanda Stinnett
Jul 13, 2007·Journal of the American Society of Nephrology : JASN·Belinda DavisLuigi Gnudi
Apr 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qin-Hui TuoJian-Xiong Chen
Jan 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew JohnstonNicole L Ward
Mar 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seth B CoffeltClaire E Lewis

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